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The Annals of Thoracic Surgery, Vol 50, 303-305, Copyright © 1990 by The Society of Thoracic Surgeons

ARTICLES

Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E1

GJ Whitman, D Martel, M Weiss, A Pochanapring, WM See, A Hopeman, AH Harken and IM Dauber
Department of Surgery, University of Colorado, Denver.

A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.


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