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Ann Thorac Surg 1990;50:40-43
© 1990 The Society of Thoracic Surgeons

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Articles

Four years' experience with fibrin sealant in thoracic and cardiovascular surgery

Department of Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia USA

^_* Address reprint requests to Dr Spotnitz, Department of Surgery, Box 181, University of Virginia Health Sciences Center, Charlottesville, VA 22908.

A single-donor fibrin sealant system was used in 689 thoracic and cardiovascular surgical procedures over the 4-year period between April 1, 1985, and March 31, 1989. An excellent overall success rate ([equation], 94% effective) was achieved with specific applications, including reduction of leakage of air ([equation], 88% effective), blood ([equation], 94% effective), and fluid ([equation], 100% effective), as well as positioning of anatomical structures such as coronary bypass grafts ([equation], 100% effective). Application methods included use of spray bottles ([equation], 96% effective), syringes ([equation], 89% effective), and a Silastic cannula through the flexible fiber-optic bronchoscope ([equation], 67% effective). The system was used in a wide variety of cardiac, pulmonary, esophageal, and vascular procedures to seal staple lines, suture lines, anastomoses, conduits, fistulas, and raw surfaces. No complications with this single-donor system secondary to blood-borne disease have been documented. Overall infection occurred at a nominal rate ([equation], 2%). Thus, fibrin sealant has been a useful tool to control the leakage of air, blood, and fluid during a wide variety of thoracic and cardiovascular procedures and may be of benefit to other surgeons.

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