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Ann Thorac Surg 1990;49:767-770
© 1990 The Society of Thoracic Surgeons

Articles

Comparison of prostacyclin production of human gastroepiploic artery and saphenous vein

Takahiko Oku, MD, PhD*, Sumiko Yamane, BS, Hisayoshi Surna, MD, PhD, Harumitsu Satoh, MD, PhD, Ryu Koike, MD, PhD, Yoshihide Sawada, MD, Atsuro Takeuchi, MD, PhD

Department of Thoracic Surgery, Osaka Medical College, Osaka, Japan

Accepted for publication December 26, 1989.

* Address reprint requests to Dr Oku, Department of Thoracic Surgery, Osaka Medical College, 2-7 Daigakucho, Takatsuki, Osaka 569, Japan.

The prostacyclin production of the gastroepiploic artery (GEA) and saphenous vein (SV) were studied in 5 patients undergoing coronary artery revascularization. The GEA produced 90.0 ± 11.9, 132.4 ± 13.7, and 191.1 ± 21.8 pg/mg tissue (mean ± standard error of the mean) of 6-keto-prostaglandin F1α (prostacyclin metabolite) after 2.5, 5.0, and 10.0 minutes, respectively, of incubation in Krebs-Henseleit buffer at 37 °C. The SV produced 39.8 ± 7.0, 66.7 ± 9.1, and 123.6 ± 15.1 pg/mg tissue of 6-keto prostaglandin F1α after 2.5, 5.0, and 10.0 minutes, respectively, of incubation. The GEA produced significantly more 6-keto-prostaglandin F1α than SV at all three sampling times up to ten minutes of incubation (p < 0.01). Prostacyclin is a potent vasodilator and an inhibitor of platelet aggregation. Prostacyclin production by the internal mammary artery was repcried to be much higher than that of SV, and the patency rate of internal mammary artery grafts is reported to be better than that of SV grafts in coronary artery revascularization. Therefore, our results suggest that the patency rate of GEA grafts may be better than that of SV grafts in coronary artery revascularization. The GEA is a promising and excellent graft from the biochemical point of view.




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