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The Annals of Thoracic Surgery, Vol 49, 413-417, Copyright © 1990 by The Society of Thoracic Surgeons

ARTICLES

Clinical trial of nicardipine cardioplegia in pediatric cardiac surgery

F Mori, M Miyamoto, H Tsuboi, H Noda and K Esato
First Department of Surgery, Yamaguchi University School of Medicine, Japan.

To clarify the effectiveness of nicardipine, one of the dihydropyridine calcium-channel blockers, for myocardial protection during cold potassium cardioplegic arrest in pediatric cardiac surgery, a clinical trial of nicardipine (0.25 mg/L) added to potassium cardioplegic solution was performed in children undergoing surgical repair of congenital heart diseases. Twenty patients were selected to receive nicardipine cardioplegia and 13 patients received a standard potassium cardioplegia, serving as a control group. Nicardipine cardioplegia provided better cardiac performance in the early postoperative period and reduced release of the MB isozyme of creatine kinase, as determined during a 48-hour postoperative period. These results suggest that nicardipine added to cold potassium cardioplegic solution offers additional protection for the myocardium during ischemia and postischemic reperfusion in pediatric cardiac surgery.


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