HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Robert L. Kormos John M. Armitage Robert L. Hardesty Bartley P. Griffith Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kormos, R. L. Articles by Griffith, B. P. Search for Related Content PubMed PubMed Citation Articles by Kormos, R. L. Articles by Griffith, B. P.

Ann Thorac Surg 1990;49:261-272
© 1990 The Society of Thoracic Surgeons

---

Articles

Experience with univentricular support in mortally ill cardiac transplant candidates

Departments of Surgery and Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania USA

^_* Address reprint requests to Dr Kormos, Department of Surgery, University of Pittsburgh, 1084 Scaife Hall, Pittsburgh, PA 15261.

Between July 1987 and March 1989, 11 patients underwent left ventricular support with the Novacor left ventricular assist system irrespective of apparent degree of right ventricular failure. The first 2 patients died of multisystem organ failure while on support. All the remaining patients survived the support period, and actuarial survival after transplantation was 100% at 6 months and 89% at 1 year. In no patient did bacterial infection develop during support or after transplantation. Right ventricular ejection fraction before implantation of the left ventricular assist system was lower than 15% in 6 of 6 patients, yet it increased twofold during left ventricular support. The need for excessive inotropic support (2 patients) or temporary (four days) mechanical right ventricular support (2 patients) while on the left ventricular support system appeared to be related to elevated pulmonary vascular resistance during support in association with large preimplantation ventricular volumes. It appears that even patients with compromised right ventricular performance can be supported long term with a left ventricular assist device. Patients with elevated pulmonary vascular resistance may require temporary right ventricular support.

This article has been cited by other articles:

				A K Mahmood, J M Courtney, S Westaby, M Akdis, and H Reul Critical review of current left ventricular assist devices Perfusion, September 1, 2000; 15(5): 399 - 420. [PDF]

				T. D.T. Tjan, B. Asfour, D. Hammel, C. Schmidt, H. H. Scheld, and C. Schmid Wound complications after left ventricular assist device implantation Ann. Thorac. Surg., August 1, 2000; 70(2): 538 - 541. [Abstract] [Full Text] [PDF]

				J. R Pepper Surgery for heart failure: options and outcomes Perfusion, July 1, 2000; 15(4): 287 - 293. [PDF]

				I. Di Bella, F. Pagani, C. Banfi, E. Ardemagni, A. Capo, C. Klersy, and M. Vigano Results with the Novacor assist system and evaluation of long-term assistance Eur J Cardiothorac Surg, July 1, 2000; 18(1): 112 - 116. [Abstract] [Full Text] [PDF]

				C. Schmid, M. Wilhelm, M. Rothenburger, D. Nabavi, M. C. Deng, D. Hammel, and H. H. Scheld Effect of high dose platelet inhibitor treatment on thromboembolism in Novacor patients Eur J Cardiothorac Surg, March 1, 2000; 17(3): 331 - 335. [Abstract] [Full Text] [PDF]

				M. Weyand, D. Kececioglu, H. G. Kehl, C. Schmid, H. M. Loick, J. Vogt, and H. H. Scheld Neonatal mechanical bridging to total orthotopic heart transplantation Ann. Thorac. Surg., August 1, 1998; 66(2): 519 - 522. [Abstract] [Full Text] [PDF]

				B. E. Jaski, J. Kim, R. S. Maly, K. R. Branch, R. Adamson, L. K. Favrot, S. C. Smith Jr, and W. P. Dembitsky Effects of Exercise During Long-term Support With a Left Ventricular Assist Device : Results of the Experience With Left Ventricular Assist Device With Exercise (EVADE) Pilot Trial Circulation, May 20, 1997; 95(10): 2401 - 2406. [Abstract] [Full Text]

				W. A. Mandarino, S. Winowich, J. Gorcsan III, T. A. Gasior, S. M. Pham, B. P. Griffith, and R. L. Kormos Right Ventricular Performance and Left Ventricular Assist Device Filling Ann. Thorac. Surg., April 1, 1997; 63(4): 1044 - 1049. [Abstract] [Full Text]

				C.-H. Park, K. Nishimura, M. Kitano, K. Matsuda, Y. Okamoto, and T. Ban ANALYSIS OF RIGHT VENTRICULAR FUNCTION DURING BYPASS OF THE LEFT SIDE OF THE HEART BY AFTERLOAD ALTERATIONS IN BOTH NORMAL AND FAILING HEARTS J. Thorac. Cardiovasc. Surg., May 1, 1996; 111(5): 1092 - 1102. [Abstract] [Full Text]

				D.G. Nabavi, D. Georgiadis, T. Mumme, C. Schmid, T.G. Mackay, H.H. Scheld, and E.B. Ringelstein Clinical Relevance of Intracranial Microembolic Signals in Patients With Left Ventricular Assist Devices : A Prospective Study Stroke, May 1, 1996; 27(5): 891 - 896. [Abstract] [Full Text]

				R. L. Kormos, T. A. Gasior, A. Kawai, S. M. Pham, S. Murali, B. G. Hattler, and B. P. Griffith TRANSPLANT CANDIDATE'S CLINICAL STATUS RATHER THAN RIGHT VENTRICULAR FUNCTION DEFINES NEED FOR UNIVENTRICULAR VERSUS BIVENTRICULAR SUPPORT J. Thorac. Cardiovasc. Surg., April 1, 1996; 111(4): 773 - 783. [Abstract] [Full Text]

				E. A. Rose and D. J. Goldstein Wearable Long-Term Mechanical Support for Patients With End-Stage Heart Disease: A Tenable Goal Ann. Thorac. Surg., January 1, 1996; 61(1): 399 - 402. [Abstract] [Full Text]

				S. M. Mehta, T. X. Aufiero, W. E. Pae Jr, C. A. Miller, and W. S. Pierce Mechanical ventricular assistance: An economical and effective means of treating end-stage heart disease Ann. Thorac. Surg., August 1, 1995; 60(2): 284 - 291. [Abstract] [PDF]

				P. M. McCarthy, R. M. Savage, C. D. Fraser, R. Vargo, K. B. James, M. Goormastic, R. E. Hobbs, and S. b. D. M. Cosgrove Hemodynamic and physiologic changes during support with an implantable left ventricular assist device J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 409 - 418. [Abstract] [Full Text]

				G. J. Cooper, D. Y. Loisance, M. Miyama, Y. Abe, and P. H. Deleuze Direct mechanical assistance of the right ventricle with the hemopump in a porcine model Ann. Thorac. Surg., February 1, 1995; 59(2): 443 - 447. [Abstract] [PDF]

				P. M. McCarthy, K. Fukamachi, F. Fukumura, K. Muramoto, L. A. R. Golding, and H. Harasaki The Cleveland Clinic-Nimbus total artificial heart: In vivo hemodynamic performance in calves and preclinical studies J. Thorac. Cardiovasc. Surg., September 1, 1994; 108(3): 420 - 428. [Abstract] [Full Text]

				K. Fujita, G. E. McGrath, T. Morita, B. L. Robinson, J. W. Davis, and J. J. Morris The effects of left heart assist on right ventricular muscle mechanics and ventricular coupling in the injured heart J. Thorac. Cardiovasc. Surg., September 1, 1994; 108(3): 477 - 486. [Abstract] [Full Text]

				D. Y. Loisance, P. H. Deleuze, J.- P. Mazzucotelli, P. Le Besnerais, and J.-L. Dubois-Rande Clinical implantation of the wearable baxter Novacor ventricular assist system Ann. Thorac. Surg., August 1, 1994; 58(2): 551 - 554. [Abstract] [PDF]

				D. Loisance, P. H. Deleuze, J. P. Mazzucotelli, Y. Abe, P. Le Besnerais, and J. L. Dubois-Rande The initial experience with the wearable Baxter Novacor ventricular assist system J. Thorac. Cardiovasc. Surg., July 1, 1994; 108(1): 176 - 177. [Full Text]

				P. M. McCarthy, N. Wang, and R. Vargo Preperitoneal insertion of the HeartMate 1000 IP implantable left ventricular assist device Ann. Thorac. Surg., March 1, 1994; 57(3): 634 - 638. [Abstract] [PDF]

				D. G. Pennington, L. R. McBride, P. S. Peigh, L. W. Miller, and M. T. Swartz Eight years' experience with bridging to cardiac transplantation J. Thorac. Cardiovasc. Surg., February 1, 1994; 107(2): 472 - 481. [Abstract] [Full Text]

				R. L. Kormos, S. Murali, M. A. Dew, J. M. Armitage, R. L. Hardesty, H. S. Borovetz, and B. P. Griffith Chronic mechanical circulatory support: Rehabilitation, low morbidity, and superior survival Ann. Thorac. Surg., January 1, 1994; 57(1): 51 - 58. [Abstract] [PDF]

				M. R. Moon, L. J. Castro, A. DeAnda, Y. Tomizawa, G. T. Daughters II, N. B. Ingels Jr, and D. C. Miller Right ventricular dynamics during left ventricular assistance in closed-chest dogs Ann. Thorac. Surg., July 1, 1993; 56(1): 54 - 67. [Abstract] [PDF]

				N. A. Burton, E. A. Lefrak, Q. Macmanus, A. Hill, J. A. Marino, A. M. Speir, B. F. Akl, R. A. Albus, and P. S. Massimiano A reliable bridge to cardiac transplantation: The TCI left ventricular assist device Ann. Thorac. Surg., June 1, 1993; 55(6): 1425 - 1431. [Abstract] [PDF]

				A. Moritz and E. Wolner Circulatory support with shock due to acute myocardial infarction Ann. Thorac. Surg., January 1, 1993; 55(1): 238 - 244. [Abstract] [PDF]

				W. S. Phillips, N. A. Burton, Q. Macmanus, and E. A. Lefrak Surgical complications in bridging to transplantation: The Thermo Cardiosystems LVAD Ann. Thorac. Surg., March 1, 1992; 53(3): 482 - 485. [Abstract] [PDF]

				J. E. Lowe, M. P. Anstadt, P. Van Trigt, P. K. Smith, P. J. Hendry, M. D. Plunkett, and G. L. Anstadt First successful bridge to cardiac transplantation using direct mechanical ventricular actuation Ann. Thorac. Surg., December 1, 1991; 52(6): 1237 - 1245. [Abstract] [PDF]

				J. M Pristas, H. S Borovetz, R. L Kormos, and B. P Griffith Biomedical engineering management of Novacor left Ventricular assist system (LVAS) patients Perfusion, July 1, 1990; 5(3): 181 - 191. [Abstract] [PDF]