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The Annals of Thoracic Surgery, Vol 49, 133-134, Copyright © 1990 by The Society of Thoracic Surgeons
AG Fleisher, KG Evans, B Nelems and RJ Finley
The effectiveness of fibrin glue as a sealant to reduce postoperative air
leaks after pulmonary lobectomy was evaluated in 28 consecutive patients
between November 1988 and May 1989. A fibrin glue spray was used in 14
patients, and 14 patients served as controls. Assignment of either group
was made before thoracotomy. Nine male and 5 female patients with a mean
age of 63.8 years were in the fibrin glue experimental group, and 8 male
and 6 female patients with a mean age of 59 years, in the control group. An
equal number of complete and incomplete fissures were in each group. All
fissures were handled in the same way (stapled). Two milliliters of fibrin
glue was applied through a double-syringe delivery system and sprayed on
the staple line and any cut surface of the inflated lung just before
thoracotomy closure. The fibrin glue-treated group had a mean air leak
duration of 2.3 +/- 3.7 days, chest tube drains for 6 +/- 4.1 days, and a
postoperative hospitalization of 9.8 +/- 3.1 days. The control group had a
mean air leak duration of 3.3 +/- 3.3 days (p = 0.94), chest tube drains
for 5.9 +/- 3.9 days (p = 0.95), and a postoperative hospitalization of
11.5 +/- 3.9 days (p = 0.21). We conclude that the routine use of a fixed
quantity of fibrin glue is not effective in reducing the duration of air
leaks, chest tube drainage, or hospitalization after uncomplicated
pulmonary lobectomy.
ARTICLES
Effect of routine fibrin glue use on the duration of air leaks after lobectomy
Department of Surgery, University of British Columbia, Vancouver General Hospital, Canada.
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