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The Annals of Thoracic Surgery, Vol 48, 838-845, Copyright © 1989 by The Society of Thoracic Surgeons
LJ Markovitz, EB Savage, MB Ratcliffe, JE Bavaria, G Kreiner, RV Iozzo, WC Hargrove 3d, DK Bogen and LH Edmunds Jr
In 28 Dorsett sheep, ligation of the distal homonymous (equivalent to human
left anterior descending) and second diagonal coronary arteries produced a
constant transmural infarct of 22.9% +/- 2.5% (mean +/- standard deviation)
of the left ventricular mass. Serial left ventriculograms showed that
within four hours the infarct segment expands, wall thickness decreases,
and aneurysmal dilatation occurs and progresses over the next 60 days in
all sheep. Epicardial ventricular point references indicated that adjacent
noninfarcted myocardium participates in the formation of the aneurysm.
Anatomy of the coronary vasculature was studied in 22 excised sheep hearts.
In sheep, coronary arterial anatomy is remarkably constant. The left
coronary artery provides all of the blood supply to the left ventricle and
septum and only a small rim of both the anterior and posterior right
ventricles. Cardiac veins from the left ventricle drain into the coronary
sinus, which also receives the left azygos vein. Right ventricular veins
drain separately. The essentially separate coronary circulations to the two
ventricles, the paucity of coronary collateral circulation, and the
consistent evolution of left ventricular infarcts into aneurysms are
important advantages of the ovine model for both metabolic and ventricular
mechanical studies of acute myocardial infarction and left ventricular
aneurysm.
ARTICLES
Large animal model of left ventricular aneurysm
Department of Surgery, University of Pennsylvania, Philadelphia 19104.
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M. B. Ratcliffe, A. W. Wallace, J. R. Teerlink, J. Hong, A. Salahieh, S.-H. Sung, E. C. Keung, and R. J. Lee RADIO FREQUENCY HEATING OF CHRONIC OVINE INFARCT LEADS TO SUSTAINED INFARCT AREA AND VENTRICULAR VOLUME REDUCTION J. Thorac. Cardiovasc. Surg., June 1, 2000; 119(6): 1194 - 1204. [Abstract] [Full Text] [PDF]
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R. J. Edwards, M. S. Marber, S. T. Kelley, R. Malekan, J. H. Gorman III, B. M. Jackson, R. C. Gorman, Y. Suzuki, T. Plappert, D. K. Bogen, et al. Restraining Infarct Expansion Preserves Left Ventricular Geometry and Function After Acute Anteroapical Infarction • Response Circulation, December 21, 1999; 100 (25): e152 - e152. [Full Text] [PDF]
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S. T. Kelley, R. Malekan, J. H. Gorman III, B. M. Jackson, R. C. Gorman, Y. Suzuki, T. Plappert, D. K. Bogen, M. G. St. J. Sutton, and L. H. Edmunds Jr Restraining Infarct Expansion Preserves Left Ventricular Geometry and Function After Acute Anteroapical Infarction Circulation, January 12, 1999; 99(1): 135 - 142. [Abstract] [Full Text] [PDF]
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 D. Li, C. Y. Li, A. C. Yong, and D. Kilpatrick Source of Electrocardiographic ST Changes in Subendocardial Ischemia Circ. Res., May 19, 1998; 82(9): 957 - 970. [Abstract] [Full Text] [PDF]
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J. H. Gorman III, R. C. Gorman, T. Plappert, B. M. Jackson, Y. Hiramatsu, M. G. St. John-Sutton, and L. H. Edmunds Jr. Infarct Size And Location Determine Development Of Mitral Regurgitation In The Sheep Model J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 615 - 622. [Abstract] [Full Text]
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F. V. DiPierro, J. E. Bavaria, E. B. Lankford, D. J. Polidori, M. A. Acker, J. T. Streicher, and T. J. Gardner Triiodothyronine Optimizes Sheep Ventriculoarterial Coupling for Work Efficiency Ann. Thorac. Surg., September 1, 1996; 62(3): 662 - 669. [Abstract] [Full Text]
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J. H. Gorman III, K. B. Gupta, J. T. Streicher, R. C. Gorman, B. M. Jackson, M. B. Ratcliffe, D. K. Bogen, and L. H. Edmunds Jr. Dynamic Three-Dimensional Imaging of the Mitral Valve and Left Ventricle by Rapid Sonomicrometry Array Localization J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 712 - 726. [Abstract] [Full Text]
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M. J. Moulton, S. W. Downing, L. L. Creswell, D. S. Fishman, D. M. Amsterdam, B. A. Szabo, J. L. Cox, and M. K. Pasque Mechanical Dysfunction in the Border Zone of an Ovine Model of Left Ventricular Aneurysm Ann. Thorac. Surg., October 1, 1995; 60(4): 986 - 997. [Abstract] [Full Text]
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