HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Shlomo Gabbay Joseph J. Amato Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gabbay, S. Articles by Khan, M. Y. Search for Related Content PubMed PubMed Citation Articles by Gabbay, S. Articles by Khan, M. Y.

Ann Thorac Surg 1989;48:803-812
© 1989 The Society of Thoracic Surgeons

---

Articles

New outlook on pericardial substitution after open heart operations

^a Departments of Surgery and Pathology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
^b Department of Electrical Engineering, New Jersey Institute of Technology, Newark, New Jersey, USA

Accepted for publication August 16, 1989.

^_* Address reprint requests to Dr Gabbay, Department of Cardiothoracic Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 100 Bergen St, Room G502, Newark, NJ 07103.

The difficulties of rcoperation owing to adhesions are well known. Clinical attempts to solve this problem using synthetic materials or glutaraldehyde-fixed pericardial xenograft have been less than satisfactory. Although experimental animal results have been good, they have not considered the influence of cardiopulmonary bypass (CPB) on adhesion formation. This study addressed the influence of CPB on the formation of adhesions and evaluated biodegradable polyglycolic add as a material to reduce adhesions and as a pericardial substitute. Forty-five weanling sheep received implants of pericardial xenograft and polyglycolic acid with and without CPB. The pericardial xenograft showed no adhesions when implanted without CPB, but severe adhesions formed and a thick fibrinous layer covered the heart when CPB was used, making identification of coronary arteries at reoperation very difficult. The polyglycolic acid mesh implanted without CPB was absorbed and replaced with newly formed host collagen. With CPB, the polyglycolic acid was more rapidly absorbed, and a thinner layer of host collagen formed. Therefore, future animal studies must include CPB. In agreement with reported clinical results, glutaraldehyde-fixed pericardial tissue implanted with CPB resulted in severe epicardial reaction and therefore is not an ideal pericardial substitute.

This article has been cited by other articles:

				G. Matsumura, T. Shin'oka, Y. Ikada, T. Sakamoto, and H. Kurosawa Novel Anti-Adhesive Pericardial Substitute for Multistage Cardiac Surgery Asian Cardiovasc Thorac Ann, August 1, 2008; 16(4): 309 - 312. [Abstract] [Full Text] [PDF]

				Y. Naito, T. Shin'oka, N. Hibino, G. Matsumura, and H. Kurosawa A novel method to reduce pericardial adhesion: A combination technique with hyaluronic acid biocompatible membrane. J. Thorac. Cardiovasc. Surg., April 1, 2008; 135(4): 850 - 856. [Abstract] [Full Text] [PDF]

				Y. Chang, P.-H. Lai, C.-C. Wang, S.-C. Chen, W.-C. Chang, and H.-W. Sung Mesothelium regeneration on acellular bovine pericardia loaded with an angiogenic agent (ginsenoside Rg1) successfully reduces postsurgical pericardial adhesions J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 867 - 874. [Abstract] [Full Text] [PDF]

				H. Tsukihara, S. Takamoto, K. Kitahori, K. Matsuda, A. Murakami, R. J. Novick, and Y. Suematsu Prevention of Postoperative Pericardial Adhesions With a Novel Regenerative Collagen Sheet Ann. Thorac. Surg., February 1, 2006; 81(2): 650 - 657. [Abstract] [Full Text] [PDF]

				K. Sakuma, A. Iguchi, Y. Ikada, and K. Tabayashi Closure of the Pericardium Using Synthetic Bioabsorbable Polymers Ann. Thorac. Surg., November 1, 2005; 80(5): 1835 - 1840. [Abstract] [Full Text] [PDF]

				K. Saha, W. McEwan, F. A Frizelle, and H. Singh Limiting Pericardial Adhesions after Coronary Artery Bypass: Experimental Study Asian Cardiovasc Thorac Ann, March 1, 2004; 12(1): 61 - 64. [Abstract] [Full Text] [PDF]

				S. Endo, N. Saito, Y. Misawa, and Y. Sohara Late pericarditis secondary to pericardial patch implantation 25 years prior Eur J Cardiothorac Surg, November 1, 2001; 20(5): 1059 - 1060. [Abstract] [Full Text] [PDF]

				N. Okuyama, C. Y. Wang, E. A. Rose, K. E. Rodgers, E. Pines, G. S. diZerega, and M. C. Oz Reduction of retrosternal and pericardial adhesions with rapidly resorbable polymer films Ann. Thorac. Surg., September 1, 1999; 68(3): 913 - 918. [Abstract] [Full Text] [PDF]

				J. Lahtinen, J. Satta, S. Lahde, I. Suramo, J. Nissinen, R. Pokela, and T. Juvonen Computed tomographic evaluation of retrosternal adhesions after pericardial substitution Ann. Thorac. Surg., October 1, 1998; 66(4): 1264 - 1268. [Abstract] [Full Text] [PDF]

				A. Hurle, M. de la Vega, J. J. Feijoo, V. G. Ray, C. Abad, G. Ponce, and J. L. Perez-Arellano Effect of Physical Protection on the Mesothelial Integrity of the Pericardium Ann. Thorac. Surg., April 1, 1997; 63(4): 1091 - 1094. [Abstract] [Full Text]

				U. U. Nkere, S. A. Whawell, C. E. Sarraf, J. B. Schofield, J. N. Thompson, and K. M. Taylor Perioperative histologic and ultrastructural changes in the pericardium and adhesions Ann. Thorac. Surg., August 1, 1994; 58(2): 437 - 444. [Abstract] [PDF]