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The Annals of Thoracic Surgery, Vol 48, 712-713, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Ancrod anticoagulation for cardiopulmonary bypass in heparin-induced thrombocytopenia and thrombosis

SJ Teasdale, VJ Zulys, T Mycyk, RJ Baird and MF Glynn
Department of Anaesthesia, Toronto General Hospital, University of Toronto, Ontario, Canada.

Heparin-induced thrombocytopenia and thrombosis was diagnosed in a 50- year-old man undergoing a repeat heart operation after heparinization led to microemboli and an eventual left transmetatarsal amputation. A third heart operation was aborted when anticoagulation with low molecular weight heparin produced intraoperative thrombi. The patient was referred to Toronto where ancrod (Arvin) was used to lower plasma fibrinogen level, allowing successful repair of a ventricular septal defect using cardiopulmonary bypass support. The patient made an uneventful recovery.

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