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Ann Thorac Surg 1989;48:646-650
© 1989 The Society of Thoracic Surgeons

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Articles

Evaluation of arterialized vein graft permeability with Evans blue dye and iodine 125-labeled albumin

^a Section of Cardiovascular and Thoracic Surgery, Mayo Clinic Jacksonville, Jacksonville, Florida USA
^b The Division of Cardiovascular Diseases and Internal Medicine and the Section of Cardiovascular Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota USA

Accepted for publication July 21, 1989.

^_* Address reprint requests to Dr Finck, Mayo Clinic Jacksonville, 4500 San Pablo Rd. Jacksonville, FL 32224.

This study measured endothelial permeability, quantitatively (with iodine 125-labeled albumin) and qualitatively (with Evans blue dye) in arterialized vein grafts in 9 adult dogs. In each dog, the right common carotid artery was ligated and arterial flow was reconstituted with a 5-cm bypass graft of right external jugular vein. Twenty-four hours before the dogs were killed, each dog received both ¹²⁵I-labeled albumin (8 µCi/kg) and Evans blue dye (15 mg/kg) intravenously. After the dogs' death, each arterialized vein graft and each left external jugular vein (as control) was harvested and studied. Arterialized vein graft permeability was significantly increased over control at 1, 3, and 6 months (3 dogs at each interval). Scanning electron microscopy revealed confluent endothelium in all specimens. This increased permeability may play a role in vein graft atherosclerosis.

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