ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Franco Alajmo
Giancarlo Calamai
Avio M. Perna
Germano Melissano
Alfredo Palminiello
Marino Vaccari
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alajmo, F.
Right arrow Articles by Vaccari, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alajmo, F.
Right arrow Articles by Vaccari, M.

Ann Thorac Surg 1989;48:536-539
© 1989 The Society of Thoracic Surgeons

Articles

High-Dose Aprotinin: Hemostatic Effects in Open Heart Operations

Franco Alajmo, MD*, Giancarlo Calamai, MD, Avio M. Perna, MD, Germano Melissano, MD, Paola Pretelli, MD, Mara F. Palmarini, MD, Fiorella Carbonetto, MD, Daniela Noferi, MD, Vieri Boddi, Alfredo Palminiello, MD, Marino Vaccari, MD

Departments of Cardiothoracic Surgery and Anesthesia, Institute of Pathology, University of Florence and Careggi Hospital, Florence, Italy

Accepted for publication June 14, 1989.

* Address reprint requests to Dr Alajmo, via Brunetto Latini 87, 50133 Firenze, Italy

Two groups of patients were prospectively studied to evaluate the hemostatic effects of high-dose aprotinin in open heart operations. Group A patients (n = 22) received aprotinin during the entire surgical procedure. Group B patients (n = 12) served as controls. The groups were homogeneous for base variables and for cardiopulmonary bypass duration. Postoperative bleeding was lower in group A (mean, 486 mL) than in group B (830 mL) (p < 0.01). The need for banked blood decreased by approximately half in the aprotinin patients (mean: group A, 213 mL; group B, 409 mL). Hemoglobin levels were similar in the two groups (postoperative day 7: group A, 11.29 g/100 mL; group B, 11.26 g/100 mL; NS). Platelet count decreased at the end of operation in both groups (99,000 and 95,000/mL, respectively; NS) and then increased beyond baseline levels before discharge. No complications were observed that could be attributed to aprotinin. In conclusion, we believe that the use of high-dose aprotinin is safe and effective. It decreases blood loss and reduces the need for banked blood in cardiac operations, particularly in select groups of patients (eg, those undergoing reoperation, Jehovah's Witnesses, those with renal failure).




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. D. McEvoy, S. T. Reeves, J. G. Reves, and F. G. Spinale
Aprotinin in Cardiac Surgery: A Review of Conventional and Novel Mechanisms of Action
Anesth. Analg., October 1, 2007; 105(4): 949 - 962.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. R. Brown, N. J.O. Birkmeyer, and G. T. O'Connor
Meta-Analysis Comparing the Effectiveness and Adverse Outcomes of Antifibrinolytic Agents in Cardiac Surgery
Circulation, June 5, 2007; 115(22): 2801 - 2813.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
The Society of Thoracic Surgeons Blood Conservatio, V. A. Ferraris, S. P. Ferraris, S. P. Saha, E. A. Hessel II, C. K. Haan, B. D. Royston, C. R. Bridges, R. S.D. Higgins, G. Despotis, et al.
Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline
Ann. Thorac. Surg., May 1, 2007; 83(5_Supplement): S27 - S86.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
A. J. Chong, C. R. Hampton, and E. D. Verrier
Microvascular Inflammatory Response in Cardiac Surgery
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 333 - 354.
[Abstract] [PDF]

Home page
 PerfusionHome page
S. V Moran, G. Lema, J. Medel, M. J Irarrazaval, R. Zalaquett, B. Garayar, and R. Flaskamp
Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery
Perfusion, March 1, 2000; 15(2): 105 - 110.
[Abstract] [PDF]

Home page
 CirculationHome page
J. J. Munoz, N. J. O. Birkmeyer, J. D. Birkmeyer, G. T. O'Connor, and L. J. Dacey
Is {epsilon}-Aminocaproic Acid as Effective as Aprotinin in Reducing Bleeding With Cardiac Surgery? : A Meta-Analysis
Circulation, January 12, 1999; 99(1): 81 - 89.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
S. Westaby
Aprotinin Fifteen Years Later
Seminars in Cardiothoracic and Vascular Anesthesia, November 1, 1997; 1(4): 366 - 375.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Cicek, U. Demirkilic, E. Kuralay, E. Ozal, and H. Tatar
Postoperative Aprotinin: Effect on Blood Loss and Transfusion Requirements in Cardiac Operations
Ann. Thorac. Surg., May 1, 1996; 61(5): 1372 - 1376.
[Abstract] [Full Text]

Home page
 PerfusionHome page
I. Rodrigus, K. Vermeyen, S. De Hert, B. Amsel, and P. Walter
Efficacy and safety of aprotinin in aortocoronary bypass and valve replacement operations: a placebo-controlled randomized double-blind study
Perfusion, January 1, 1996; 11(4): 313 - 318.
[Abstract] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. P. Wendel, W. Heller, J. Michel, G. Mayer, C. Ochsenfahrt, U. Graeter, J. Schulze, H.-M. Hoffmeister, and H.-E. Hoffmeister
Lower cardiac troponin T levels in patients undergoing cardiopulmonary bypass and receiving high-dose aprotinin therapy indicate reduction of perioperative myocardial damage
J. Thorac. Cardiovasc. Surg., June 1, 1995; 109(6): 1164 - 1172.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
J. A. Rousou, R. M. Engelman, J. E. Flack III, D. W. Deaton, and S. G. Owen
Tranexamic acid significantly reduces blood loss associated with coronary revascularization
Ann. Thorac. Surg., March 1, 1995; 59(3): 671 - 675.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. E. Fremes, B. I. Wong, E. Lee, R. Mai, G. T. Christakis, R. F. McLean, B. S. Goldman, and C. D. Naylor
Metaanalysis of prophylactic drug treatment in the prevention of postoperative bleeding
Ann. Thorac. Surg., December 1, 1994; 58(6): 1580 - 1588.
[Abstract] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. R. Shainoff, F. G. Estafanous, J.-P. Yared, P. M. DiBello, K. Kottke-Marchant, and F. D. Loop
Low factor XIIIA levels are associated with increased blood loss after coronary artery bypass grafting
J. Thorac. Cardiovasc. Surg., September 1, 1994; 108(3): 437 - 445.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
F. Herynkopf, F. Lucchese, E. Pereira, R. Kalil, P. Prates, and I. A. Nesralla
Aprotinin in children undergoing correction of congenital heart defectsA double-blind pilot study
J. Thorac. Cardiovasc. Surg., September 1, 1994; 108(3): 517 - 521.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
M. Kawasuji, K. Ueyama, N. Sakakibara, T. Tedoriya, Y. Matsunaga, T. Misaki, and Y. Watanabe
Effect of low-dose aprotinin on coagulation and fibrinolysis in cardiopulmonary bypass
Ann. Thorac. Surg., May 1, 1993; 55(5): 1205 - 1209.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Westaby
Aprotinin in perspective
Ann. Thorac. Surg., April 1, 1993; 55(4): 1033 - 1041.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Tatar, S. [i. ] [image]i[image]ek, U. Demirkili[image], E. Ozal, H. Suer, O. Ozturk, and H. Isiklar
Topical use of aprotinin in open heart operations
Ann. Thorac. Surg., March 1, 1993; 55(3): 659 - 661.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. M. Najman, J. M. Walenga, J. Fareed, and R. Pifarre
Effects of aprotinin on anticoagulant monitoring: Implications in cardiovascular surgery
Ann. Thorac. Surg., March 1, 1993; 55(3): 662 - 666.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. Lavee, Z. Raviv, A. Smolinsky, N. Savion, D. Varon, D. A. Goor, and R. Mohr
Platelet protection by low-dose aprotinin in cardiopulmonary bypass: Electron microscopic study
Ann. Thorac. Surg., January 1, 1993; 55(1): 114 - 119.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. M. Cosgrove III, B. Heric, B. W. Lytle, P. C. Taylor, R. Novoa, L. A. R. Golding, R. W. Stewart, P. M. McCarthy, and F. D. Loop
Aprotinin therapy for reoperative myocardial revascularization: A placebo-controlled study
Ann. Thorac. Surg., December 1, 1992; 54(6): 1031 - 1038.
[Abstract] [PDF]

Home page
 VASC ENDOVASCULAR SURGHome page
E. Santoli, D. G. Di Mattia, P. Castelli, A. Condemi, S. Guzzetti, P. Meraviglia, and C. Santoli
Reduction of Homologous Transfusions in Open-Heart Surgery
Vascular and Endovascular Surgery, November 1, 1992; 26(9): 693 - 699.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Alajmo and G. Calamai
High-dose aprotinin in emergency coronary artery bypass after thrombolysis
Ann. Thorac. Surg., November 1, 1992; 54(5): 1022 - 1022.
[PDF]

Home page
 Ann. Thorac. Surg.Home page
M. P. Harder, L. Eijsman, K. J. Roozendaal, W. van Oeveren, and C. R. H. Wildevuur
Aprotinin reduces intraoperative and postoperative blood loss in membrane oxygenator cardiopulmonary bypass
Ann. Thorac. Surg., June 1, 1991; 51(6): 936 - 941.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. K. Kirklin
Prospects for understanding and eliminating the deleterious effects of cardiopulmonary bypass
Ann. Thorac. Surg., April 1, 1991; 51(4): 529 - 531.
[PDF]

Home page
 Ann. Thorac. Surg.Home page
G. M. Guiraudon, G. J. Klein, R. Yee, R. Kaushik, D. G. McLellan, and D. M. Cade
Surgical epicardial ablation of left ventricular pathway using sling exposure
Ann. Thorac. Surg., December 1, 1990; 50(6): 968 - 971.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. Santoli, R. Scrofani, and C. Santoli
How should the risk of bank blood transfusion in open heart operations be minimized?
Ann. Thorac. Surg., December 1, 1990; 50(6): 1021 - 1022.
[PDF]

Home page
 Ann. Thorac. Surg.Home page
R. W. M. Frater
Aprotinin and open heart operations
Ann. Thorac. Surg., May 1, 1990; 49(5): 851 - 852.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1989 by The Society of Thoracic Surgeons.