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Ann Thorac Surg 1989;48:417-420
© 1989 The Society of Thoracic Surgeons

Articles

Surgical Preparation Impairs Release of Endothelium-Derived Relaxing Factor From Human Saphenous Vein

G.D. Angelini, MD*, M.I. Christie, BSc, A.J. Bryan, FRCS, M.J. Lewis, PhD

Department of Cardiac Surgery, University Hospital of Wales, and Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, Wales

Accepted for publication June 14, 1989.

* Address reprint requests to Dr Angelini, Department of Cardiac Surgery, University Hospital of Wales, Heath Park, Cardiff CF4 4XN, Wales

Release of endothelium-derived relaxing factor was measured from freshly isolated human saphenous vein and from vein subject to routine surgical preparation for coronary artery bypass grafting. Surgical preparation led to a significant decline in endothelium-derived relaxing factor release as compared with freshly isolated vein, and these changes were associated with loss of endothelial coverage. Storage of freshly isolated vein in blood but not in Hartmann's solution also resulted in a decline in maximally stimulated endothelium-derived relaxing factor release that was not associated with loss of endothelium. Reduced production of endothelium-derived relaxing factor, a potent vasodilator and inhibitor of platelet adhesion and aggregation, may be implicated in the etiology of early vein graft thrombosis.




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