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Ann Thorac Surg 1989;48:109-112
© 1989 The Society of Thoracic Surgeons

Articles

Embryonic versus adult myocardium: Adenine nucleotide degradation during ischemia

William Kenneth Mask, MD, Anwar S. Abd-elfattah, PhD, Michael Jessen, MD, Louis A. Brunsting, MD, Jon Lekven, MD, Andrew S. Wechsler, MD*

Department of Surgery, Duke University Medical Center, Durham, North Carolina USA

Accepted for publication February 20, 1989.

* Address reprint requests to Dr Wechsler, Chairman, Department of Surgery, Box 645, Medical College of Virginia, Richmond, VA 23398.

Neonatal myocardium demonstrates better recovery from ischemia than does adult tissue. We tested the hypothesis that developmental differences in adenine nucleotide degradation might facilitate recovery by quantitating depletion of high-energy phosphates in nine-day-old embryonic (n = 9) and 15-month-old adult (n = 14) chicken hearts at 15-, 30-, 45-, and 60-minute intervals of normothermic ischemia in vitro. Nucleotides adenosine triphosphate, adenosine diphosphate, and adenosine monopnosphate and nucleosides adenosine, inosine, hypoxanthine, and xanthine were determined by highperformance liquid chromatography. Several observations in metabolite degradative response to ischemia were noted. The embryonic myocardium maintained higher adenosine triphosphate and adenosine monophosphate levels over the course of the investigation than did mature myocardium. Moreover, the adult group showed an increase in diffusible nucleoside pool metabolites. Relative immaturity of enzymes responsible for nucleotide degradation may facilitate postiachemic recovery by preserving nondiffusible high-energy phosphate precursors to participate in salvage resynthesis of adenosine triphosphate.




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