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Ann Thorac Surg 1989;47:939-945
© 1989 The Society of Thoracic Surgeons
Department of Cardiovascular Surgery and INSERM U-127, Hôpital Lariboisière, Paris, France
* Address reprint requests to Dr Menasché, Service de Chirurgie Cardio-Vasculaire, Hôpital Lariboisière, 2 rue Ambroise Paré, 75010 Paris, France.
Oxygen-derived free radicals are now considered important contributors to tissue injury associated with ischemia and reperfusion. Transition metals primarily iron, greatly enhance the generation of these active species, which can destroy a large variety of biomolecules, in particular the lipid components of cell membranes. This review tries to demonstrate why cardiopulmonary bypass and aortic cross-clamping are situations that predispose to oxygen free radical production, and how "antifree radical" agents such as enzymatic scavengers, antioxidants, and iron chelators may prove to be useful therapeutic radicals in the clinical setting of open heart surgery.
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