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Ann Thorac Surg 1989;47:857-859
© 1989 The Society of Thoracic Surgeons

Articles

Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics

Doris Sue, PharmD, Theresa A. Salazar, PharmD, Kevin Turley, MD, B.Joseph Guglielmo, PharmD*

Division of Clinical Pharmacy and Department of Surgery, University of California, San Francisco, California USA

Accepted for publication December 9, 1988.

* Address reprint requests to Dr Guglielmo, Division of Clinical Pharmacy, University of California, San Francisco, C-152 Box 0622, San Francisco, CA 94143.

Antibiotic prophylaxis is used widely to prevent postoperative infection associated with cardiac operations. The influence of perioperative blood loss on antibiotic pharmacokinetics has not been well studied. Plasma cefazolin sodium samples from 8 patients undergoing a cardiac operation were collected postoperatively and analyzed. The results suggest that blood loss has a minimal effect on the elimination of cefazolin and that therapeutic concentrations are maintained without altering the dosage regimen.




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S. M. Swoboda, C. Merz, J. Kostuik, B. Trentler, and P. A. Lipsett
Does Intraoperative Blood Loss Affect Antibiotic Serum and Tissue Concentrations?
Arch Surg, November 1, 1996; 131(11): 1165 - 1172.
[Abstract] [PDF]


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