| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1989;47:809-815
© 1989 The Society of Thoracic Surgeons
Section of Thoracic Surgery, The University of Michigan Medical Center, Ann Arbor, Michigan USA
* Address reprint requests to Dr Bolling, The University of Michigan Hospital, 2120D Taubman Center, Box 0344, 1500 E Medical Center Dr, Ann Arbor, MI 48109.
This study was undertaken to investigate whether adenosine administered during cardioplegic arrest could enhance myocardial protection and improve recovery of function after ischemia. Isolated perfused rabbit hearts were subjected to 120 minutes of hypothermic (32 °C) multidose cardioplegia-induced ischemia. Control hearts (n = 23) received modified St. Thomas's cardioplegia, and the remaining hearts received cardioplegia with either 100 µM (n = 11), 200 µM (n = 11), or 400 µM (n = 11) adenosine. After ischemia and 45 minutes of reperfusion, left ventricular contractility was superior in all groups of adenosine-treated hearts compared with control hearts. Furthermore, there was a significant incremental increase in functional recovery with increasing dose of adenosine. Postischemic diastolic stiffness was significantly better in all adenosine groups compared with controls. No differences were noted in coronary flow or myocardial water content between adenosinetreated and control hearts. These data demonstrate that adenosine administered in these concentrations provides myocardial protection and improved recovery of both systolic and diastolic function after global ischemia, presumably metabolically by reducing depletion of adenosine triphosphate or enhancing repletion of adenosine triphosphate and enabling improved postischemic recovery.
This article has been cited by other articles:
|
|
 |
|
  B. G. Fogelson, S. I. Nawas, and W. R. Law MECHANISMS OF MYOCARDIAL PROTECTION BY ADENOSINE-SUPPLEMENTED CARDIOPLEGIC SOLUTION: MYOFILAMENT AND METABOLIC RESPONSES J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 601 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Spinale Cellular and molecular therapeutic targets for treatment of contractile dysfunction after cardioplegic arrest Ann. Thorac. Surg., November 1, 1999; 68(5): 1934 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vinten-Johansen, V. H. Thourani, R. S. Ronson, J. E. Jordan, Z.-Q. Zhao, M. Nakamura, D. Velez, and R. A. Guyton Broad-spectrum cardioprotection with adenosine Ann. Thorac. Surg., November 1, 1999; 68(5): 1942 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L Zarro, D. A Palanzo, and F. S Sadr Myocardial preconditioning using adenosine: review and clinical experience Perfusion, March 1, 1998; 13(2): 145 - 150. [Abstract] [PDF]
|
|
|
|
|
|
M. H. Cox, S.-J. O, L. Hebbar, R. Mukherjee, F. A. Crawford Jr, and F. G. Spinale Protective Effects of Adenosine on Myocyte Contractility During Cardioplegic Arrest Ann. Thorac. Surg., April 1, 1997; 63(4): 981 - 987. [Abstract] [Full Text]
|
|
|
|
|
|
O. Katayama, S. J. M. Ledingham, M. Amrani, R. T. Smolenski, D. R. Lachno, J. Jayakumar, and M. H. Yacoub Functional and Metabolic Effects of Adenosine in Cardioplegia: Role of Temperature and Concentration Ann. Thorac. Surg., February 1, 1997; 63(2): 449 - 454. [Abstract] [Full Text]
|
|
|
|
|
|
A. K. Pridjian, E. D. Frohlich, C. H. VanMeter, P. M. McFadden, and J. L. Ochsner Pharmacologic support with high-energy phosphate preservation in the postischemic neonatal heart Ann. Thorac. Surg., June 1, 1995; 59(6): 1435 - 1440. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Hudspeth, K. Nakanishi, J. Vinten-Johansen, Z.-Q. Zhao, D. S. McGee, M. W. Williams, and J. W. Hammon Jr Adenosine in blood cardioplegia prevents postischemic dysfunction in ischemically injured hearts Ann. Thorac. Surg., December 1, 1994; 58(6): 1637 - 1644. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Hudspeth, M. W. Williams, Z.-Q. Zhao, H. Sato, K. Nakanishi, D. S. McGee, J. W. Hammon Jr, J. Vinten-Johansen, and D. G. L. Van Wylen Pentostatin-augmented interstitial adenosine prevents postcardioplegia injury in damaged hearts Ann. Thorac. Surg., September 1, 1994; 58(3): 719 - 727. [Abstract] [PDF]
|
|
|
|
|
|
S. F. Bolling, D. A. Olszanski, K. F. Childs, K. P. Gallagher, and X.-H. Ning Stunning, preconditioning, and functional recovery after global myocardial ischemia Ann. Thorac. Surg., September 1, 1994; 58(3): 822 - 827. [Abstract] [PDF]
|
|
|
|
|
|
R. D. Lasley and R. M. Mentzer Jr. The role of adenosine in extended myocardial preservation with the University of Wisconsin solution J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1356 - 1363. [Abstract] [Full Text]
|
|
|
|
|
|
J. Nissinen, M. J. P. Raatikainen, K. Karlqvist, and K. J. Peuhkurinen Efflux of adenosine and its catabolites during cold blood cardioplegia Ann. Thorac. Surg., June 1, 1993; 55(6): 1546 - 1552. [Abstract] [PDF]
|
|
|
|
|
|
S. E. Fremes, R. D. Furukawa, R.-K. Li, R. D. Weisel, D. A. G. Mickle, and L. C. Tumiati Comparison of two experimental models for assessment of cardiac preservation Ann. Thorac. Surg., January 1, 1993; 55(1): 144 - 150. [Abstract] [PDF]
|
|
|
|
|
|
S. F. Bolling, M. A. Groh, A. M. Mattson, R. A. Grinage, and K. P. Gallagher Acadesine (AICA-riboside) improves postischemic cardiac recovery Ann. Thorac. Surg., July 1, 1992; 54(1): 93 - 98. [Abstract] [PDF]
|
|
|
|
|
|
T. L. Demmy, J. A. Magovern, R. L. Kao, and G. J. Magovern Resuscitation of injured myocardium with adenosine and biventricular assist Ann. Thorac. Surg., November 1, 1991; 52(5): 1044 - 1051. [Abstract] [PDF]
|
|
|
|
|
|
S. E. Fremes, R.-K. Li, R. D. Weisel, D. A. G. Mickle, R. D. Furukawa, and L. C. Tumiati The limits of cardiac preservation with University of Wisconsin solution Ann. Thorac. Surg., October 1, 1991; 52(4): 1021 - 1025. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
