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Ann Thorac Surg 1989;47:806-808
© 1989 The Society of Thoracic Surgeons

Articles

Large cell carcinoma of the lung: A highly aggressive tumor with dismal prognosis

Richard S. Downey, MD, C.Whitaker Sewell, MD, Kamal A. Mansour, MD*

Division of Thoracic and Cardiovascular Surgery, The Joseph B. Whitehead Department of Surgery, and Department of Pathology, Emory University School of Medicine, Atlanta, Georgia USA

Accepted for publication September 21, 1983.

* Address reprint requests to Dr Mansour, The Emory Clinic, 1365 Clifton Rd, NE, Atlanta, GA 30322.

A retrospective review was made of 96 consecutive patients with large cell carcinoma of the lung admitted to Emory University Hospital over 10 years. Only 10 patients were seen with stage I lesions favorable for resection. The remainder were treated primarily with irradiation or chemotherapy. Mean survival for clinical stage I patients was 15.9 months; stage IIIA patients, 7.9 months; stage IIIB patients, 7.1 months; and stage IV patients, 5.8 months. Only 1 patient survived for 5 years. This distinct and highly aggressive form of lung cancer most commonly is seen at an advanced stage and is associated with an unusually dismal prognosis regardless of the method of treatment employed.




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