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Ann Thorac Surg 1989;47:741-745
© 1989 The Society of Thoracic Surgeons

Articles

True thymic hyperplasia: A clinicopathological study

C. Ricci, MD, FCCP, E. Pescarmona, MD, E.A. Rendina, MD*, F. Venuta, MD, L.P. Ruco, MD, C.D. Baroni, MD

Department of Thoracic Surgery and II Chair of Pathologic Anatomy, University of Rome "La Sapienza," Rome, Italy

Accepted for publication November 28, 1988.

* Address reprint requests to Dr Rendina, Cattedra di Chirurgia Toracica, II Clinica Chirurgica, Policlinico Limberto I, 00161 Roma, Italy.

In this report, we describe the clinicopathological features of 4 patients with true thymic hyperplasia. This controversial thymic lesion has only recently been defined as a variable, often massive enlargement of the thymus characterized by a nearly normal microscopic structure. Our study of 4 patients and review of the literature indicate that true thymic hyperplasia has a well-defined clinicopathological profile: prevalence in children or young male patients, absence of associated autoimmune diseases, and often presence of respiratory distress or peripheral blood lymphocytosis, or both. True thymic hyperplasia should be considered in the differential diagnosis of anterior mediastinal masses in children and young adolescents.




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F. Nasseri and F. Eftekhari
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RadioGraphics, March 1, 2010; 30(2): 413 - 428.
[Abstract] [Full Text] [PDF]


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