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Ann Thorac Surg 1989;47:553-557
© 1989 The Society of Thoracic Surgeons
Department of Clinical Biochemistry and Division of Cardiovascular Surgery, Toronto General Hospital, University of Toronto, and Division of Chemistry, National Research Council of Canada, Ottawa, Ontario, Canada
* Address reprint requests, to Dr Mickle, Toronto General Hospital. Department of Clinical Biochemistry, ES3-404, 200 Elizabeth St. Toronto, Ont M5G 2C4 Canada.
Both Trolox (a water-soluble analogue of α-tocopherol) and ascorbic acid were more effective than superoxide dismutase or catalase in protecting myocyte cell cultures from free radical attack (induced by hypoxanthine and xanthine oxidase). In a canine model of two hours of left anterior descending coronary artery occlusion followed by four hours of reperfusion, Trolox and ascorbic acid reduced the area of infarction within the area at risk. The Trolox group received 500 mL of deoxygenated saline solution containing 2.0 g of Trolox, 3.0 g of ascorbic acid, and 18 mg of EDTA (ethylenediaminetetraacetic acid) infused into the ascending aorta 30 seconds before and four minutes after reperfusion. Saline controls received 500 mL of deoxygenated saline solution containing 18 mg of EDTA. The angioplasty group had unmodified reperfusion by simple release of the occlusion. The area at risk and the area infarcted were estimated with Evans blue and triphgnyl tetrazolium hydiochloride stains, respectively. The ratio of the area infarcted to the area at risk was significantly lower with Trolox (angioplasty, 33.4% ± 5.1%; saline, 20.8% ± 2.9%; and Trolox, 8.7% ± 4.0%; p < 0.01). In summary, the antioxidants Trolox and ascorbic acid effectively reduced myocardial necrosis after ischemia.
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