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Ann Thorac Surg 1989;47:346-351
© 1989 The Society of Thoracic Surgeons
a Albany Medical College, Albany, New York, USA
b The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
* Address reprint requests to Dr Moores, Division of Cardiothoracic Surgery, ME-514/A-62 Albany Medical College, Albany, NY 12208.
Three hundred thirty patients with non-small cell lung cancer were evaluated to assess the effect of perioperative blood transfusion on overall survival and time to recurrence. One hundred sixty-nine patients received blood products during the perioperative period, and 161 received none. The mean length of follow-up was 3.6 years. There were 90 recurrences, including second primaries, and 99 deaths in the group receiving transfusion; in the group without transfusion, recurrent cancer developed in 74 patients, and 68 died. Survival comparisons, adjusted for stage and cell type using the stratified log-rank statistic, showed significant reduction in survival (p = 0.007) for patients receiving transfusion. Time to recurrence was shorter for patients receiving transfusion (p = 0.035), but became less significant when adjusted for both cell type and stage (p = 0.11). Blood transfusion within the perioperative period appears to have an adverse effect on survival and recurrence in patients undergoing surgical resection for lung cancer.
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