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Ann Thorac Surg 1989;47:187-192
© 1989 The Society of Thoracic Surgeons

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Articles

Reperfusion injury in the lung preserved for 24 hours

Division of Cardiothoracic Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

^_* Address reprint requests to Dr Paull, CB 7065, 108 Burnett-Womack Building, University of North Carolina, Chapel Hill, NC 27599-7065.

The left lower lobes of 28 canine lungs were isolated, preserved, and then reperfused for 150 minutes. Five groups of lobes were studied: group 1, control (n = 5); group 2, one hour of warm ischemia (n = 5); group 3, one hour of warm ischemia + oxygen free radical scavengers (n = 5); group 4, 24 hours of cold ischemia (n = 8); and group 5, 24 hours of cold ischemia + oxygen free radical scavengers (n = 5). Oxygen free radical scavengers consisted of superoxide dismutase and catalase (100 µg/mL) given at the moment of reflow. Extravascular lung water (grams per gram of blood-free dry lobe weight) after reperfusion was 2.75 ± 0.19, 5.46 ± 0.60, 4.08 ± 0.37, 9.43 ± 0.98, and 6.91 ± 0.95 for groups 1 through 5, respectively (p < 0.05, groups 2 through 5 versus group 1; p < 0.05, group 2 versus group 3 and group 4 versus group 5), Lung tissue lipid peroxidation, measured as thiobarbituric add reactive material, was 117 ± 14, 314 ± 19, and 163 ± 25 nmol/g dry lobe weight for groups 1, 4, and 5, respectively (p < 0.05, group 4 versus group 1 and group 4 versus group 5). The data suggest that oxygen free radical scavengers attenuate reperfusion injury after long-term hypothermic lung preservation.

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