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Ann Thorac Surg 1988;46:661-665
© 1988 The Society of Thoracic Surgeons

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Articles

The Temporal Relationship in Arterial and Venous Prostacyclin and Thromboxane Activity during 24 Hours of Intraaortic Balloon Counterpulsation in Dogs

Departments of Surgery, Meharry Medical College, Nashville, TN, and the Brooklyn Veterans Administration Medical Center, and the Division of Cardiology, Brooklyn Veterans Administration Medical Center and the State University of New York Health Science Center at Brooklyn, Brooklyn, NY

Accepted for publication July 28, 1988.

^* Address reprint requests to Dr. Hoover, Department of Surgery, Meharry Medical College, 1005 D. B. Todd Blvd, Nashville, TN 37208

We studied the effects of intraaortic balloon counterpulsation (IABCP) on prostacyclin (PGI₂) and thromboxane (TXB₂) levels in dogs during 24 hours of 1:1 IABCP or a sham procedure in which the balloon was positioned but left deflated. The arterial PGI₂ levels in the IABCP group increased from control values of 95 ± 20 pg/ml to 268 ± 95 pg/ml at 1 hour, 429 ± 95 pg/ml at 4 hours, and 1,884 ± 532 pg/ml at 24 hours. The arterial PGI₂ levels were consistently higher in the IABCP group. Although the TXB₂ measurements revealed no significant differences between groups, the IABCP group consistently had a higher level than the sham group. The platelet count in the control group decreased to 45% of baseline levels versus 55% for the IABCP group.

We conclude that prolonged IABCP results in either net production of PGI₂ or decreased degradation. The correlation between TXB₂ and platelet counts is unclear and remains to be defined.

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