HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Ko Bando Shigeru Teramoto Mamoru Tago Taiji Murakami Yoshimasa Senoo Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bando, K. Articles by Senoo, Y. Search for Related Content PubMed PubMed Citation Articles by Bando, K. Articles by Senoo, Y.

Ann Thorac Surg 1988;46:625-630
© 1988 The Society of Thoracic Surgeons

---

Articles

Core-Cooling, Heart-Perfusion, Lung-Immersion Technique Provides Successful Cardiopulmonary Preservation for Heart-Lung Transplantation

Department of Surgery II, Okayama University Medical School, Okayama, Japan

Accepted for publication June 29, 1988.

^* Address reprint requests to Dr. Teramoto, Department of Surgery, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, 700, Japan

Mongrel dogs underwent heterotopic heart-orthotopic left lung transplantation. In Group I (N = 6), donor organs procured following core cooling to 15°C on cardiopulmonary bypass (CPB) with cardioplegic arrest were immediately transplanted. In Group II (N = 6), following cardioplegic arrest without CPB core-cooling, the pulmonary artery was flushed with modified Collins' solution. Heart-lung blocks were immersed in extracellular solution for 6 hours and then transplanted. In Groups III and IV (N = 6 each), following CPB core-cooling to 15°C and cardioplegic arrest, the organ blocks were immersed in extracellular solution (Group III) and the heart was perfused with oxygenated extracellular solution (Group IV). Evaluation of lung function using differences in arterial oxygen tension between the left and right atria demonstrated no differences between groups. However, extravascular lung water and pulmonary vascular resistance were significantly elevated in Group II. Cardiac function assessed by the ratio of end-systolic pressure to end-systolic dimension was significantly better in Group IV than in Groups II and III. Thus, adequate 6-hour hypothermic cardiopulmonary preservation with core cooling plus heart perfusion can be achieved for heart-lung transplantation.