HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Ronald M. Weintraub Robert L. Thurer Robert Johnson Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shannon, R. P. Articles by Wei, J. Y. Search for Related Content PubMed PubMed Citation Articles by Shannon, R. P. Articles by Wei, J. Y.

Ann Thorac Surg 1988;46:430-437
© 1988 The Society of Thoracic Surgeons

---

Articles

Impact of Acute Reduction in Chronically Elevated Left Atrial Pressure on Sodium and Water Excretion

Charles A. Dana Research Institute and Harvard Thorndike Laboratory of the Beth Israel Hospital, Departments of Mediane and Surgery, Beth Israel Hospital and Harvard Medical School, Boston, MA

Accepted for publication May 3, 1988.

^* Address reprint requests to Dr. Wei, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215

To test the hypothesis that a reduction in chronically elevated left atrial pressure would decrease sodium and water excretion in humans, we studied 61 carefully selected patients who underwent cardiac surgery for valvular or coronary artery disease or both.

The immediate postoperative decrease in left atrial pressure (from 16.7 ± 1.0 to 9.4 ± 0.4 mm Hg; p > 0.001) was inversely correlated with postoperative urine output (r = –0.69; p > 0.001) and sodium excretion (r = –0.51; p > 0.005). There was no significant relationship between postoperative urine output or sodium excretion and other hemodynamic or nonhemodynamic variables. A significant postoperative decrease in plasma atrial natriuretic factor (from 150 ± 22 to 65 ± 14 pg/ml; p > 0.01) and increase in plasma renin activity (from 2.5 ± 0.6 to 8.7 ± 3.2; p > 0.05) occurred in patients with a 7 mm Hg or greater postoperative decrease in left atrial pressure.

Thus, an acute reduction in left atrial pressure results in significant reductions in urine output and sodium excretion, the magnitude of which are related to the degree of reduction in left atrial pressure.

This article has been cited by other articles:

				K. M. Davis, L. C. Fish, D. Elahi, B. A. Clark, and K. L. Minaker Atrial Natriuretic Peptide Levels in the Prediction of Congestive Heart Failure Risk in Frail Elderly JAMA, May 20, 1992; 267(19): 2625 - 2629. [Abstract] [PDF]

				M. Hynynen, M. Salmenpera, A. L. J. Harjula, I. Tikkanen, F. Fyhrquist, and J. Heinonen Atria1 pressure and hormonal and renal responses to acute cardiac tamponade Ann. Thorac. Surg., April 1, 1990; 49(4): 632 - 637. [Abstract] [PDF]