HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rao, B. N. Articles by Hustu, H. O. Search for Related Content PubMed PubMed Citation Articles by Rao, B. N. Articles by Hustu, H. O.

Ann Thorac Surg 1988;46:40-44
© 1988 The Society of Thoracic Surgeons

---

Articles

Chest Wall Resection for Ewing's Sarcoma of the Rib: An Unnecessary Procedure

Division of Surgery, Hematology-Oncology, and Radiation Oncology, St. Jude Children's Research Hospital and the Departments of Surgery, Pediatrics and Radiation Oncology, the University of Tennessee, Memphis, Memphis, TN

^* Address reprint requests to Dr. Rao, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38101

Approximately 10% of all cases of Ewing's sarcoma arise from a rib. Conventional management has included chest wall resection (3 or more ribs) and radiation therapy. These forms of therapy have led to complications such as scoliosis and local deformity. The addition of radiation therapy can result in damage to the lung and adjacent viscera and also potentiate pulmonary restrictive disease. Between 1971 and 1978, 9 patients were treated with surgery, radiation therapy, and combination chemotherapy (three- or four-drug regimen). Only 2 patients (22%) survive. Since 1979, 14 patients were entered into a new protocol consisting of sequential induction chemotherapy, followed by delayed surgical resection whenever feasible. Three patients had complete resection of their primary lesion at onset. Initially, 7 patients had either biopsy (N = 4) or incomplete chest wall resection N = 3). All 4 patients with biopsy only at diagnosis had excellent responses to induction chemotherapy, allowing delayed resection of the involved rib without chest wall resection. Overall, 12 of 14 patients (86%) treated since 1979 survive, with only 2 receiving radiation therapy for residual disease in the primary rib site.

This article has been cited by other articles:

				R. C. Shamberger, M. P. LaQuaglia, M. D. Krailo, J. S. Miser, D. J. Pritchard, M. C. Gebhardt, J. H. Healey, N. J. Tarbell, C. J.H. Fryer, P. A. Meyers, et al. EWING SARCOMA OF THE RIB: RESULTS OF AN INTERGROUP STUDY WITH ANALYSIS OF OUTCOME BY TIMING OF RESECTION J. Thorac. Cardiovasc. Surg., June 1, 2000; 119(6): 1154 - 1161. [Abstract] [Full Text] [PDF]

				B. N. Rao, F. A. Hayes, E. I. Thompson, A. P. M. Kumar, I. D. Fleming, A. A. Green, B. A. Austin, J. W. Pate, and H. O. Hustu Chest wall resection for ewing's sarcoma of the rib: an unnecessary procedure Ann. Thorac. Surg., November 1, 1995; 60(5): 1454 - 1455. [Abstract] [PDF]