ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Amin Mohamed G. Addetia
Graham W.M. Walsh
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Addetia, A. M. G.
Right arrow Articles by Reid, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Addetia, A. M. G.
Right arrow Articles by Reid, P.

Ann Thorac Surg 1988;45:482-488
© 1988 The Society of Thoracic Surgeons

Articles

Prolonged Asystole during Intraoperative Myocardial Reperfusion: An Experimental Study

Amin Mohamed G. Addetia, M.B., Ch.B., F.R.C.S.(C)*, Bill F. O'Reilly, C.C.P., Graham W.M. Walsh, C.C.P., Patricia Reid, R.A.

From the Health Sciences Complex, Memorial University of Newfoundland, St. John's, Nfld, Canada

Accepted for publication September 28, 1987.

* Address reprint requests to Dr. Addetia, Department of Surgery, Health Sciences Complex, Memorial University of Newfoundland, St. John's, Nfld, Canada A1B 3V6

It has been observed in a proportion of patients, that clinically cardiac asystole persists for a prolonged period during intraoperative reperfusion. To evaluate this phenomenon, isovolumic functional indices (left ventricular [LV] balloon) and myocardial oxygen consumption (MVO 2) were compared in 22 canine preparations before and after two different interventions. After 45 minutes of normothermic global ischemia, (1) the control group (N = 11) was maintained on cardiopulmonary bypass with the hearts beating empty and (2) the experimental group (N = 11) was subjected to cardioplegia reperfusion at normothermia for one hour. In contradistinction to the initial hypothesis, functional recovery was better in the experimental group compared with the controls. Significant differences were observed in recovery of LV peak developed pressure (LVPDP) (controls, 66.8 ± 7.3% [mean ± standard error of the mean], and experimental group, 99.5 ± 8.9% p < 0.05), maximum rate of rise of LV pressure (controls, 116.6 ± 16.2%, and experimental group, 147.7 ± 10.1% p < 0.05), and maximum fall of LV pressure (controls, 100.3 ± 15.8%, and experimental group, 143.1 ± 11.5% p < 0.05). Correlation between LVPDP and MVO 2 was also better preserved in the experimental group (controls: r = 0.15, N = 74, p = 0.18; experimental group: r = 0.47, N = 75, p < 0.001). Values for myocardial water content and total creatine kinase in the two groups were similar. It was concluded that prolonged asystole during intraoperative reperfusion is not detrimental; on the contrary, there is enhanced functional recovery of the myocardium similar to that seen after secondary cardioplegia.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
H. L. Lazar
Prolonged Asystole during Intraoperative Myocardial Reperfusion
Ann. Thorac. Surg., December 1, 1988; 46(6): 711 - 711.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1988 by The Society of Thoracic Surgeons.