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The Annals of Thoracic Surgery, Vol 45, 409-414, Copyright © 1988 by The Society of Thoracic Surgeons
BP Griffith, RL Kormos, RL Hardesty, JM Armitage and JS Dummer
Between October, 1985, and September, 1987, a total of 195 patients
received cardiac allografts and 15 candidates required mechanical support
with the Jarvik-7 total artificial heart. Seven of the 15 died within 60
days of total artificial heart implant. There have been no late deaths, and
survivors are unrestricted. Six of 7 deaths were related to infection
(mediastinitis, 5; pneumonia and sepsis, 1), and the remaining 1 was due to
failure of the transplanted heart. Respiratory tract infection occurred in
each of the recipients who died with infection, and the same organisms
appeared to be related to subsequent mediastinitis in 3 patients (Serratia
marcescens, 2; Pseudomonas, 1) and caused fatal sepsis in another
(Enterobacter aerogenes, Candida albicans). One patient died with pneumonia
and sepsis prior to transplantation, and another succumbed with mediastinal
infection known to be present before transplantation.
ARTICLES
The artificial heart: infection-related morbidity and its effect on transplantation
Department of Surgery, University of Pittsburgh, PA 15261.
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