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Ann Thorac Surg 1988;45:390-392
© 1988 The Society of Thoracic Surgeons

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Articles

Prostacyclin production in free versus native IMA grafts

From the Department of Thoracic and Cardiovascular Surgery and the Childrens Hospital, Helsinki University Central Hospital, Helsinki, Finland

Accepted for publication November 23, 1987.

^_* Address reprint requests to Dr. Aarnio, Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Haartmaninkatu 4, SF-00290 Helsinki, Finland.

The long-term patency of the internal mammary artery (IMA) in coronary artery surgery has been superior to that of other grafts. We tested the IMAs as free grafts in an experimental study with 8 dogs. The right IMA was dissected free as a naked energy artery surrounding tissue, and the left IMA one dissected with surrounding tissue using electrocautery. Both free IMA grafts were anastomosed first to the left IMA one after another and then to the left anterior descending coronary artery. The grafts were harvested 6 months later, and the prostacyclin (PGI₂) production of the free IMA grafts and of the intact IMAs was measured. Radioimmunoassay was used to measure 6-keto-prostaglandin F_1α, the stable metabolite of PGI₂. The PGI₂ production of the right free IMA without surrounding tissue was 21.1 ± 8.5 pg/mg and of the left IMA with surrounding tissue was 17.9 ± 7.9 pg/mg (expressed in picograms of 6-keto-prostaglandin F_1α per milligram of tissue wet weight). The control value of the intact IMA was 18.3 ± 6.5 pg/mg. Thus, PGI₂ production of both free IMAs did not differ significantly from each other and from controls. This study showed that free IMAs were able to produce as much PGI₂ as were control IMAs and that the type of dissection did not affect the result.

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