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The Annals of Thoracic Surgery, Vol 45, 370-379, Copyright © 1988 by The Society of Thoracic Surgeons
N Martini, MG Kris, RJ Gralla, MS Bains, PM McCormack, LR Kaiser, ME Burt and MB Zaman
We have defined "clinical N2" disease in non-small cell lung cancer to mean
the presence of enlarged metastatic mediastinal nodes evident on plain
chest roentgenograms or widening of the carina at bronchoscopy. Forty-one
patients with non-small cell carcinoma of the lung and clinical N2 M0
disease presumed operable received 2 to 3 cycles of high- dose cisplatin
with vindesine (or vinblastine sulfate) with or without mitomycin-C.
Following chemotherapy, 30 patients (73%) had a major radiographic
response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had
complete resection of the disease, 8 of whom had total sterilization of the
tumor proven histologically. An additional 4 patients had limited
microscopic foci of residual tumor either in lung or lymph nodes. Survival
at 3 years from diagnosis was 34% for all patients, 40% for those who
completed the combined treatment (chemotherapy and surgery), and 54% for
those who had complete resection with a median follow-up of 44 months and a
median survival not yet attained.
ARTICLES
The effects of preoperative chemotherapy on the resectability of non- small cell lung carcinoma with mediastinal lymph node metastases (N2 M0)
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.
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