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Ann Thorac Surg 1988;45:306-310
© 1988 The Society of Thoracic Surgeons

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Articles

Temperature Dependency of Calcium-Induced Reperfusion Injury in the Isolated Rat Heart

From the Second Department of Surgery, Tottori University School of Medicine, Yonago, Japan

Accepted for publication October 22, 1987.

^* Address reprint requests to Dr. Mori, the Second Department of Surgery, Tottori University School of Medicine, Nishi-machi 36-1, Yonago, Tottori 683, Japan

The temperature dependence of Ca-induced reperfusion injury was studied in an isolated rat heart preparation. Hearts were subjected to 90 minutes of hypothermic arrest (20°C) followed by 15 minutes of reperfusion at 20, 28, or 37°C with a reperfusate containing various concentrations of Ca (0.1–2.55 mM). When reperfusion was started at 37°C, the Ca concentration in the reperfusate significantly affected both postischemic functional recovery and creatine kinase leakage. Bell-shaped dose-response curves were observed. The optimal Ca concentration for 37°C reperfusion was between 0.3 and 0.7 mM. When reperfusion was started at 20°C, neither functional recovery nor creatine kinase leakage was dependent on the Ca concentration in the reperfusate. At 28°C, functional recovery was not dependent on the Ca concentration, however, creatine kinase leakage was. These results indicate that Ca-induced reperfusion injury depends on the temperature of the reperfusate and that the boundary temperature of the reperfusate at which Ca-induced reperfusion injury becomes manifest seems to be near 28°C.

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