HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Charles D. Fraser, Jr. Hideo Adachi George J. Kontos, Jr. Bruce A. Reitz William A. Baumgartner Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fraser, C. D. Articles by Baumgartner, W. A. Search for Related Content PubMed PubMed Citation Articles by Fraser, C. D., Jr. Articles by Baumgartner, W. A.

Ann Thorac Surg 1988;45:253-257
© 1988 The Society of Thoracic Surgeons

---

Articles

Donor Core-Cooling Provides Improved Static Preservation for Heart-Lung Transplantation

From Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD

^* Address reprint requests to Dr. Baumgartner, Division of Cardiac Surgery, The Johns Hopkins Hospital, 601 N Wolfe St, Blalock 618, Baltimore, MD 21205

Twenty-three dairy calves underwent heart-lung allotransplantation after donor organs were procured using either donor core-cooling through cardiopulmonary bypass (CPB) or pulmonary artery flush (PAF) to assess which method provides optimal graft preservation. In Groups 1 (control) and 2, donors were cooled to 15°C on CPB and organs were either immediately transplanted (Group 1) or stored in saline solution (4°C) for 4 hours (Group 2) prior to transplantation. In Group 3, donors were pretreated with prostaglandin E₁ prior to PAF with modified Euro-Collins solution. Organs were stored in saline solution (4°C) for 4 hours and were then transplanted. Acute cardiopulmonary function following transplantation was assessed by the ratio of end-systolic pressure to end-systolic dimension, extravascular lung water (EVLW), lung compliance, arterial oxygenation, and lung biopsy. Cardiac function after the transplantation procedure was similar in all groups, but EVLW values and lung biopsy scores were worse after PAF. Arterial O₂ tension appeared lower after PAF, but not significantly so. Core-cooling provides superior static preservation and thus improved graft function in the acute bovine model.

This article has been cited by other articles:

				D. V. Raemdonck, M. Struber, F. Venuta, D. Vlasselaers, W. Wisser, and M. E. Erasmus Strategies in the prevention and the treatment of ischaemia-reperfusion injury after lung transplantation Surgery for Non-Neoplastic Disorders of the Chest: a Clinical Update, June 28, 2010; 66 - 88. [Abstract] [Fulltext] [PDF]

				L. K. von Segesser Cardiopulmonary support and extracorporeal membrane oxygenation for cardiac assist Ann. Thorac. Surg., August 1, 1999; 68(2): 672 - 677. [Abstract] [Full Text] [PDF]

				A. J. B. Kirk, I. W. Colquhoun, and J. H. Dark Lung preservation: A review of current practice and future directions Ann. Thorac. Surg., October 1, 1993; 56(4): 990 - 1000. [Abstract] [PDF]

				R. J. Novick, K. R. Reid, L. Denning, J. Duplan, A. H. Menkis, and F. Neil McKenzie Prolonged preservation of canine lung allografts: The role of prostaglandins Ann. Thorac. Surg., May 1, 1991; 51(5): 853 - 859. [Abstract] [PDF]

				Y. M. LeGal Lung and heart-lung transplantation Ann. Thorac. Surg., May 1, 1990; 49(5): 840 - 844. [Abstract] [PDF]

				M. Zenati, R. D. Dowling, J. M. Armitage, R. L. Kormos, J. S. Dummer, R. L. Hardesty, and B. P. Griffith Organ procurement for pulmonary transplantation Ann. Thorac. Surg., December 1, 1989; 48(6): 882 - 886. [Abstract] [PDF]

				W. A. Baumgartner, T. A. Traill, D. E. Cameron, J. D. Fonger, I. B. Birenbaum, and B. A. Reitz Unique Aspects of Heart and Lung Transplantation Exhibited in the 'Domino-Donor' Operation JAMA, June 2, 1989; 261(21): 3121 - 3125. [Abstract] [PDF]