HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Kenneth G. Warner Miguel Josa Michael D. Butler Ernest M. Barsamian Shukri F. Khuri Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Warner, K. G. Articles by Khuri, S. F. Search for Related Content PubMed PubMed Citation Articles by Warner, K. G. Articles by Khuri, S. F.

Ann Thorac Surg 1988;45:75-81
© 1988 The Society of Thoracic Surgeons

---

Articles

Regional Changes in Myocardial Acid Production during Ischemic Arrest: A Comparison of Sanguineous and Asanguineous Cardioplegia

From the Departments of Surgery, Brockton/West Roxbury Veterans Administration Medical Center, West Roxbury, Brigham and Women's Hospital, Boston, and Harvard Medical School, Boston, MA

Accepted for publication August 28, 1987.

^* Address reprint requests to Dr. Khuri, Surgical Service, VA Medical Center, 1400 VFW Parkway, West Roxbury, MA 02132

Regional differences in myocardial acid production have not been characterized during administration of either asanguineous or sanguineous cardioplegia. To investigate this, miniature glass pH electrodes were placed in the right ventricular (RV) myocardium, the left ventricular subendocardial (LV endo) region, and the subepicardial (LV epi) region in a canine model. Multiple doses of either blood cardioplegia (Group 1; N = 11) or crystalloid cardioplegia (Group 2; N = 11) were administered during 4 hours of aortic cross-clamping. The accumulation of hydrogen ions during the cross-clamp period was greater in Group 2 than Group 1 in the LV endo region (629 ± 79 nm/L versus 66 ± 31 nm/L; p < 0.001), the LV epi region (623 ± 66 nm/L versus 72 ± 32 nm/L; p < 0.001), and the RV myocardium (814 ± 296 nm/L versus 150 ± 54 nm/L; p < 0.05). Within each group, the time course of myocardial pH and the accumulation of hydrogen ions did not differ among the LV endo region, LV epi region, and the RV myocardium (p = not significant). These data indicate that transmural and interventricular differences in myocardial pH and hydrogen ion accumulation are not produced in the vented, arrested canine heart. In addition, when compared with asanguineous cardioplegia, blood cardioplegia globally and transmurally reduces acid accumulation during ischemic arrest.

This article has been cited by other articles:

				J. A. Dearani, T. C. Axford, M. A. Patel, N. A. Healey, P. T. Lavin, and S. F. Khuri Role of myocardial temperature measurement in monitoring the adequacy of myocardial protection during cardiac surgery Ann. Thorac. Surg., December 1, 2001; 72(6): S2235 - S2243. [Abstract] [Full Text] [PDF]

				K. G. Warner, M. G. Sheahan, S. M. Arebi, A. Banerjee, J. M. Deiss-Shrem, and K. R. Khabbaz Proper timing of blood cardioplegia in infant lambs: superiority of a multiple-dose regimen Ann. Thorac. Surg., March 1, 2001; 71(3): 872 - 876. [Abstract] [Full Text] [PDF]

				P. Menasche Blood Cardioplegia: Do We Still Need to Dilute? Ann. Thorac. Surg., October 1, 1996; 62(4): 957 - 960. [Full Text]

				M. Carrier, A. Tourigny, N. Thoribe, M. Montpetit, A. Khalil, B. C. Solymoss, and L. C. Pelletier Effects of cold and warm blood cardioplegia assessed by myocardial pH and release of metabolic markers Ann. Thorac. Surg., September 1, 1994; 58(3): 764 - 767. [Abstract] [PDF]

				S. F. Khuri Invited commentary Ann. Thorac. Surg., June 1, 1994; 57(6): 1595 - 1596. [PDF]