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Ann Thorac Surg 1987;44:398-403
© 1987 The Society of Thoracic Surgeons

Articles

Valve Replacement in Children: Guidelines for Selection of Prosthesis and Timing of Surgical Intervention

Michel N. Ilbawi, M.D.*, Farouk S. Idriss, M.D., Serafin Y. DeLeon, M.D., Alexander J. Muster, M.D., C. Elise Duffy, M.D., Samuel S. Gidding, M.D., Milton H. Paul, M.D.

From the Divisions of Cardiovascular-Thoracic Surgery and Cardiology, the Children's Memorial Hospital, and the Departments of Surgery and Pediatrics, Northwestern University Medical School, Chicago, IL

Accepted for publication April 2, 1987.

* Address reprint requests to Dr. Ilbawi, Division of Cardiovascular-Thoracic Surgery, the Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614

One hundred fifty-nine patients ranging from 3 months to 18 years old (mean, 8.1 ± 3.7 years) underwent 162 primary valve implantations. A porcine valve was used in 104 patients, a St. Jude Medical valve in 40, and a Björk-Shiley valve in 18. The valve replaced was the aortic in 25 patients, the mitral (systemic atrioventricular [AV] valve) in 43, the pulmonary in 71, and the tricuspid (pulmonary AV valve) in 23. Hospital mortality was 6%. Patients with a Björk-Shiley valve received warfarin sodium anticoagulation, and those with a St. Jude Medical valve were given salicylates and dipyridamole. Follow-up is available on all patients 0.6 to 12 years postoperatively (mean, 6.3 ± 2.6 years). New York Heart Association Functional Class improved in 62% and remained unchanged in 38% of the patients. Thromboembolic complications occurred in only 8 (57%) of 14 patients with a St. Jude Medical valve in the right (pulmonary) side and in 3 (12%) of 26 with the valve in the left (systemic) side of the circulation. Bacterial endocarditis developed in 3 patients, all with porcine valves. Early valve replacement, less than 2 years after detection of hemodynamic deterioration, resulted in improvement in the ventricular ejection fraction in 25 of 29 patients (from 81 ± 14% to 90 ± 12% of normal; p < 0.05). In contrast, the ejection fraction remained abnormal in all 22 patients with delayed valve insertion (more than 2 years) (81 ± 16% of normal preoperatively and 80 ± 10% of normal following operation; p = not significant). Actuarial functional life, free from all prosthesis-related complications including major hemodynamic abnormalities, was 92 ± 6% for right-sided and 67 ± 8% for left-sided porcine valves versus 47 ± 3% for right-sided and 88 ± 7% for left-sided St. Jude Medical valves at 5 years. The data indicate that the St. Jude Medical valve has excellent durability and hemodynamic function in the left (systemic) side without need of warfarin anticoagulation. The good long-term performance of right-sided (pulmonary circulation) porcine valves encourages their continued use for tricuspid and pulmonary valve replacements. Timely valve insertion can preserve myocardial function.




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