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Ann Thorac Surg 1987;43:522-526
© 1987 The Society of Thoracic Surgeons

Articles

Regional Myocardial Perfusion of Cardioplegic Solutions

John Eugene, M.D.*, Kenneth P. Lyons, M.D., Richard A. Ott, M.D., Vincent L. Gelezunas, Ph.D., Cherylee W.J. Chang, B.S., Mark G. Kowall, B.A., Nick J. Haiduc, C.C.P.

From the Departments of Surgery and Nuclear Medicine, Veterans Administration Medical Center, Long Beach, and the University of California, Irvine, CA

Accepted for publication July 4, 1986.

* Address reprint requests to Dr. Eugene, VA Medical Center, Long Beach, Department of Surgery (112), 5901 E Seventh St, Long Beach, CA 90822

We compared the regional myocardial perfusion of blood cardioplegic solution (BCP) and crystalloid cardioplegic solution (CCF) in 14 mongrel dogs. Cardiopulmonary bypass was established at 28°C, and a hydraulic occluder was placed around the proximal left anterior descending (LAD) coronary artery. In group 1 (N = 7) collateral coronary arteries were ligated; in group 2 (N = 7) collateral coronary arteries were left in situ. After the aorta was clamped, BCP and CCP were alternately perfused at 200 ml/min. The occluder was inflated to produce moderate, severe, and critical LAD stenosis, and regional perfusion was measured by xenon-133 washout with the Silicon Avalanche Radiation Detector. BCP infusion produced a consistently higher aortic pressure, but CCP flow was better than BCP flow under all conditions, particularly without coronary collaterals (p < .05). Regional myocardial perfusion of CCP is superior to BCP.






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Copyright © 1987 by The Society of Thoracic Surgeons.