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The Annals of Thoracic Surgery, Vol 43, 406-408, Copyright © 1987 by The Society of Thoracic Surgeons
A Skupin, F Gomez, M Husain, C Skupin and O Bigman
To explore the possibility of performing percutaneous lung biopsy safely in
patients mechanically ventilated with positive-end expiratory pressure
(PEEP), transthoracic needle biopsy was performed in 16 anesthetized
mongrel dogs mechanically ventilated with 10 cm H2O of PEEP. To obtain the
biopsy sample, a 25-gauge "skinny needle" was passed through a 20-gauge
sheath and placed up to 6.25 cm deep. After satisfactory samples were
obtained, both needles were withdrawn in the control group, but in the
treated group, the outer sheath was used to inject 0.5 ml of isobutyl
2-cyanoacrylate to seal the needle track. Pneumothorax was present in 7
(87.5%) of 8 dogs in the control group and in 2 (25%) of 8 dogs in the
treated group (p = .0147). Lung tissue exhibited an apparent foreign-body
granulomatous inflammatory reaction. This technique could extend the
benefits of transthoracic needle biopsy to mechanically ventilated
patients, but further studies to prove the safety of isobutyl
2-cyanoacrylate are necessary.
ARTICLES
Complications of transthoracic needle biopsy decreased with isobutyl 2- cyanoacrylate: a pilot study
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