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Ann Thorac Surg 1987;43:386-390
© 1987 The Society of Thoracic Surgeons

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Articles

Cerebral Blood Flow and Autoregulation During Hypothermic Cardiopulmonary Bypass

Departments of Thoracic Surgery, Anesthesiology, and Clinical Neurophysiology, University Hospital, Lund, Sweden

Accepted for publication June 18, 1986.

^* Address reprint requests to Dr. Johnsson, Dept of Thoracic Surgery, University Hospital, S-221 85 Lund, Sweden

Mean hemispheric cerebral blood flow (CBF) was studied following intravenous or intraarterial administration of xenon-133, in 10 men admitted for coronary-artery bypass grafting. Repeated CBF measurements were performed to evaluate autoregulation before, during, and after cardiopulmonary bypass (CPB). During CPB mean CBF remained unchanged compared with the pre-CPB level, without evidence of cerebral hyperemia or impairment of autoregulation. A marked increase in CBF occurred after CPB and was followed by a time-dependent reduction toward the pre-CPB level. The data support the α-stat regulation theory but cannot explain the cerebral vasodilation observed after CPB.

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