HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Novitzky, D. Articles by Reichart, B. Search for Related Content PubMed PubMed Citation Articles by Novitzky, D. Articles by Reichart, B.

Ann Thorac Surg 1987;43:288-294
© 1987 The Society of Thoracic Surgeons

---

Articles

Pathophysiology of Pulmonary Edema Following Experimental Brain Death in the Chacma Baboon

From the Departments of Cardiothoracic Surgery and Pathology, Groote Schuur Hospital and the University of Cape Town Medical School, Cape Town, Republic of South Africa

Accepted for publication May 8, 1986.

^* Address reprint requests to Dr. Novitzky, Department of Cardiothoracic Surgery, University of Cape Town Medical School, Cape Town, Republic of South Africa 7925

Systemic and pulmonary hemodynamics have been studied during the induction of brain death in the chacma baboon. In 11 animals brain death was induced by acute intracranial hypertension. Continuous recording of blood flow through both the pulmonary artery and the aorta was obtained by electromagnetic flow meters placed around these vessels. Mean arterial, central venous, pulmonary arterial, and left atrial pressures were recorded continuously. Systemic and pulmonary vascular resistances were calculated. During the agonal period marked sympathetic activity occurred, with significant increases in circulating catecholamines and systemic vascular resistance. The great increase in systemic resistance resulted in acute left ventricular failure. Mean left atrial or pulmonary capillary wedge pressure rose above the mean pulmonary arterial pressure in 9 animals. As the systemic vascular resistance rose, a significant difference between pulmonary artery and aortic blood flows occurred, leading to blood pooling within the lungs. A mean of 72% of the total blood volume of the animal accumulated within these organs. The increase of left atrial pressure to levels higher than pulmonary artery pressure indicated a state of pulmonary capillary blood flow arrest. This, associated with the blood pooling within the lungs, almost certainly resulted in disruption of the anatomic integrity of the pulmonary capillaries (blast injury); 4 animals developed pulmonary edema, with alveolar septal interstitial hemorrhage.

This article has been cited by other articles:

				D. W. McKeown, R. S. Bonser, and J. A. Kellum Management of the heartbeating brain-dead organ donor Br. J. Anaesth., January 1, 2012; 108(suppl_1): i96 - i107. [Abstract] [Full Text] [PDF]

				S. Sammani, K.-S. Park, S. R. Zaidi, B. Mathew, T. Wang, Y. Huang, T. Zhou, Y. A. Lussier, A. N. Husain, L. Moreno-Vinasco, et al. A Sphingosine 1-Phosphate 1 Receptor Agonist Modulates Brain Death-Induced Neurogenic Pulmonary Injury Am. J. Respir. Cell Mol. Biol., November 1, 2011; 45(5): 1022 - 1027. [Abstract] [Full Text] [PDF]

				P. Botha, J. H. Dark, and A. J. Fisher Donor selection Lung Transplantation, June 7, 2010; 81 - 87. [Abstract] [Fulltext] [PDF]

				D. Van Raemdonck, A. Neyrinck, G. M. Verleden, L. Dupont, W. Coosemans, H. Decaluwe, G. Decker, P. De Leyn, P. Nafteux, and T. Lerut Lung Donor Selection and Management Proceedings of the ATS, January 15, 2009; 6(1): 28 - 38. [Abstract] [Full Text] [PDF]

				R. V. Venkateswaran, V. B. Patchell, I. C. Wilson, J. G. Mascaro, R. D. Thompson, D. W. Quinn, R. A. Stockley, J. H. Coote, and R. S. Bonser Early Donor Management Increases the Retrieval Rate of Lungs for Transplantation Ann. Thorac. Surg., January 1, 2008; 85(1): 278 - 286. [Abstract] [Full Text] [PDF]

				S. C. Stoica, D. K. Satchithananda, C. Atkinson, P. A. White, A. N. Redington, M. Goddard, T. Kealey, and S. R. Large The energy metabolism in the right and left ventricles of human donor hearts across transplantation Eur J Cardiothorac Surg, April 1, 2003; 23(4): 503 - 512. [Abstract] [Full Text] [PDF]

				T. M. Aziz, A. El-Gamel, R. A.G. Saad, M. Migliore, C. S. Campbell, and N. A. Yonan Pulmonary vein gas analysis for assessing donor lung function Ann. Thorac. Surg., May 1, 2002; 73(5): 1599 - 1604. [Abstract] [Full Text] [PDF]

				M. J A Parr, S. R Finfer, and M. K Morgan Lesson of the Week: Reversible cardiogenic shock complicating subarachnoid haemorrhage BMJ, September 14, 1996; 313(7058): 681 - 683. [Full Text]

				R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314. [Abstract] [Full Text]

				T. A. D'Amico, C. H. Meyers, T. C. Koutlas, D. S. Peterseim, D. C. Sabiston Jr., P. Van Trigt, and D. A. Schwinn Desensitization of myocardial {beta}-adrenergic receptors and deterioration of left ventricular function after brain death J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 746 - 751. [Abstract] [Full Text]