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Ann Thorac Surg 1987;43:87-91
© 1987 The Society of Thoracic Surgeons

Articles

Simultaneous Cisplatin Fluorouracil Infusion and Radiation Followed by Surgical Resection in Regionally Localized Stage III, Non–Small Cell Lung Cancer

Samuel G. Taylor, IV, M.D.*, Marion Trybula, M.D., Philip D. Bonomi, M.D., L. Penfield Faber, M.D., Myung-Sook Lee, M.D., Salitha Reddy, M.D., Susan C. Maffey, M.D., Douglas J. Mathisen, M.D., Robert J. Jensik, M.D., C. Frederick Kittle, M.D.

From the Section of Medical Oncology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL

Accepted for publication February 26, 1986.

* Address reprint requests to Dr. Taylor, Section of Medical Oncology, Rush-Presbyterian-St. Luke's Medical Center, Suite 830, 1725 W Harrison St, Chicago, IL 60612

Sixty-four patients with stage III (M0) non–small cell lung cancel were treated with cisplatin fluorouracil infusion chemotherapy and simultaneous radiation therapy for 5 days every other week. A total of 4 cycles (40 Gy) was followed by attempted surgical resection. Clinical response to the preoperative treatment included 5 (8%) complete and 32 (48%) partial responses. Thirty-nine (61%) underwent the planned operation, and in 9 (23%) of these patients the resected specimens were histologically negative. Clinical assessment failed to predict histological response. With 17 months median follow-up (range, 2.4–29 months), estimated 1-year survival was 61% and median survival was 16 months for all patients.




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