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The Annals of Thoracic Surgery, Vol 43, 87-91, Copyright © 1987 by The Society of Thoracic Surgeons


ARTICLES

Simultaneous cisplatin fluorouracil infusion and radiation followed by surgical resection in regionally localized stage III, non-small cell lung cancer

SG Taylor 4th, M Trybula, PD Bonomi, LP Faber, MS Lee, S Reddy, SC Maffey, DJ Mathisen, RJ Jensik and CF Kittle

Sixty-four patients with stage III (M omicron) non-small cell lung cancer were treated with cisplatin fluorouracil infusion chemotherapy and simultaneous radiation therapy for 5 days every other week. A total of 4 cycles (40 Gy) was followed by attempted surgical resection. Clinical response to the preoperative treatment included 5 (8%) complete and 32 (48%) partial responses. Thirty-nine (61%) underwent the planned operation, and in 9 (23%) of these patients the resected specimens were histologically negative. Clinical assessment failed to predict histological response. With 17 months median follow-up (range, 2.4-29 months), estimated 1-year survival was 61% and median survival was 16 months for all patients.


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Copyright © 1987 by The Society of Thoracic Surgeons.