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Ann Thorac Surg 1986;41:560-562
© 1986 The Society of Thoracic Surgeons

Articles

Neuroendocrine Carcinoma of Lung Associated with Bradycardia and Episodic Cardiac Asystole

Herbert C. Maier, M.D., Med.Sc.D.*, Sheldon C. Sommers, M.D.

Departments of Surgery and Pathology, Lenox Hill Hospital, New York, NY

Accepted for publication August 3, 1985.

* Address reprint requests to Dr. Maier, 50 East 77th St, New York, NY 10021

A neuroendocrine carcinoma of the lung associated with bradycardia and episodic cardiac asystole is reported. Cardiac dysfunction may have been caused by a hormonal factor produced by a carcinoma developing in the pulmonary neuroepithelial bodies because the bradycardia and periods of asystole disappeared after pneumonectomy, only to return months later when pleural metastatic tumor developed. No neoplastic involvement of the heart was present. Implications of a cholinesterase isoenzyme involvement in the cardiac dysfunction are discussed.




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