ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Mario Chiavarelli
Benedetto Marino
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chiavarelli, M.
Right arrow Articles by Marino, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chiavarelli, M.
Right arrow Articles by Marino, B.

Ann Thorac Surg 1986;41:535-541
© 1986 The Society of Thoracic Surgeons

Articles

Calcium Entry Blockers and Cardioplegia: Interaction Between Nifedipine, Potassium, and Hypothermia

Mario Chiavarelli, M.D.*, Roberto Chiavarelli, M.D., Arnaldo Macchiarelli, M.D., Amilcare Carpi, M.D., Benedetto Marino, M.D.

Department of Cardiac Surgery, University of Rome, and the Department of Organ and System Pathophysiology, Istituto Superiore di Sanità, Rome, Italy

Accepted for publication August 15, 1985.

* Address reprint requests to Dr. Mario Chiavarelli, Department of Surgery, Mayo Clinic, Rochester, MN 55905

The potential additive protective effect provided by nifedipine to the University of Alabama Hospitals cardioplegia solution (ACS) was assessed with the use of a guinea pig heart-lung model of cardiopulmonary bypass and ischemic arrest. The addition of nifedipine consistently enhanced the protective properties of ACS infused at 37°C; functional recovery was similar to that observed with cold ACS. Despite the additional protection under normothermic conditions, nifedipine did not improve recovery after infusion at 4°C. The abolition by hypothermia of the protective effects of nifedipine suggests a similarity in action between nifedipine and hypothermic protection.

The interaction between ACS and nifedipine was studied on bovine coronary arteries in vitro. Nifedipine caused a marked reduction in the coronary vasoconstricting effect of ACS, both under normothermic and hypothermic conditions.

The use of nifedipine in cardioplegia may provide additional protection when uneven distribution of the cardioplegic solution is expected and hypothermic protection is unreliable.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
M. Chiavarelli, F. Fabi, T. Stati, R. Chiavarelli, and P. del Basso
Effects of cardioplegic solutions and their components on human saphenous vein contractility
Ann. Thorac. Surg., March 1, 1992; 53(3): 455 - 459.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1986 by The Society of Thoracic Surgeons.