HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Irvin Krukenkamp Norman Silverman Ara Pridjian Sidney Levitsky Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Krukenkamp, I. Articles by Levitsky, S. Search for Related Content PubMed PubMed Citation Articles by Krukenkamp, I. Articles by Levitsky, S.

Ann Thorac Surg 1986;41:407-412
© 1986 The Society of Thoracic Surgeons

---

Articles

Oxygen Utilization during Isovolumic Pressure-Volume Loading: Effects of Prolonged Extracorporeal Circulation and Cardioplegic Arrest

Departments of Surgery and Pharmacology, University of Illinois College of Medicine at Chicago

Accepted for publication July 2, 1985.

^* Address reprint requests to Dr. Silverman, Department of Surgery, P.O. Box 6998, Chicago, IL 60680

In canine hearts supported by cardiopulmonary bypass, isovolumic peak developed pressure (PDP, mm Hg) and myocardial oxygen consumption (MVO₂, ml O₂ x 10^–2/beat/100 gm left ventricular [LV] weight) were determined at 5-ml increments of LV balloon inflation before and after either 2 hours of potassium cardioplegic arrest (ischemia, N = 7) or a comparable period of normothermic perfusion without ischemia (control, N = 6). The sensitivity of MVO₂ as a marker of ischemic injury was compared with preservation of both adenosine triphosphate (ATP) stores and systolic pump function. Over a physiological range of end-diastolic volumes (5 to 35 ml) and end-diastolic pressures (0 to 18 mm Hg), the Frank-Starling curves were not depressed following both cardioplegic arrest and prolonged nonischemic perfusion. Although ATP stores decreased by 26% and 22% (ischemia and control groups, respectively; not significant), these levels did not distinguish the effects of cardioplegic arrest from prolonged perfusion. At the preinterventional measurement in both groups, PDP between 50 and 200 correlated with MVO₂ from 3.0 to 10.0 (r = + 0.84). Following cardioplegic arrest, postischemic MVO₂ increased 137 ± 6% when measured over the PDP range of 75 to 200 mm Hg (p < 0.01). This change was not evident at a PDP of less than 75, in the empty beating heart, or in control hearts subjected to nonischemic extracorporeal perfusion. These data suggest that increased utilization of oxygen to develop physiological pressures may be a more sensitive indicator of ischemic injury than shifts in the pressure-volume relationship or depletion of adenine nucleotide stores.

This article has been cited by other articles:

				C. M. Dyke, K. F. Lee, J. Parmar, R. J. Dignan, T. Yeh Jr, A. Abd-Elfattah, and A. S. Wechsler Inotropic stimulation and oxygen consumption in a canine model of dilated cardiomyopathy Ann. Thorac. Surg., October 1, 1991; 52(4): 750 - 758. [Abstract] [PDF]

				A. M. G. Addetia, B. F. O'Reilly, G. W. M. Walsh, and P. Reid Prolonged Asystole during Intraoperative Myocardial Reperfusion: An Experimental Study Ann. Thorac. Surg., May 1, 1988; 45(5): 482 - 488. [Abstract] [PDF]

				I. B. Krukenkamp, N. A. Silverman, D. Sorlie, A. Pridjian, and S. Levitsky Temperature-Specific Effects of Adjuvant Diltiazem Therapy on Myocardial Energetics Following Potassium Cardioplegic Arrest Ann. Thorac. Surg., December 1, 1986; 42(6): 675 - 680. [Abstract] [PDF]