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Ann Thorac Surg 1986;41:301-306
© 1986 The Society of Thoracic Surgeons

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Articles

Hypothermic Preservation of the Heart and Lungs with Collins Solution: Effect on Cardiorespiratory Function Following Heart-Lung Allotransplantation in Dogs

From the Departments of Anesthesia and Cardiovascular Surgery, Stanford University School of Medicine, Stanford, CA 94305

Accepted for publication June 6, 1985.

^* Address reprint requests to Dr. Feeley, Department of Anesthesia, S-278, Stanford University School of Medicine, Stanford, CA 94305

The effect of preserving the heart and lungs with hypothermia and Collins solution was studied in 13 mongrel dogs undergoing combined heart-lung transplantation. The five control animals who underwent an immediate transplant following Collins solution perfusion had small increases in extravascular lung water when measured 2.5 hours posttransplant as seen in a previous study. The eight animals who had hypothermic preservation following Collins solution perfusion had significantly higher extravascular lung water than controls (16.3 ± 1.8 ml/kg in preserved animals; 11.2 ± 1.7 ml/kg in controls p < 0.05). The level of lung water reached at 2.5 hours postoperatively was similar to that reached with a previously reported, unacceptable preservation technique. Survival beyond this point was poor due to severe pulmonary edema. We conclude that the use of this solution, given under the experimental conditions which we describe, is not acceptable for hypothermic preservation of the heart and lungs for combined transplantation.

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