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The Annals of Thoracic Surgery, Vol 41, 260-264, Copyright © 1986 by The Society of Thoracic Surgeons

ARTICLES

Study on myocardial contractility after cardiopulmonary bypass versus cardioplegic arrest in an air-ejecting in vivo heart model

AM Addetia, SV Lichtenstein, AS Ko, M Sikkonen, M Sainani and TA Salerno

Cardiac function was assessed in a working in vivo canine heart preparation. Minute work and myocardial oxygen consumption (MVo2) were measured after a two-hour period of hypothermic hyperkalemic crystalloid cardioplegic arrest in one group of dogs (Group 1, N = 6) and in another group of dogs on cardiopulmonary bypass (CPB) alone (Group 2, N = 6). Results indicate that at an afterload of 50 cm H2O, minute work was the same in all hearts but MVo2 was significantly higher in Group 1 hearts at all levels of preload. At higher afterloads, both minute work and MVo2 were significantly greater in Group 1 hearts over the range of preloads tested. Ventricular compliance was decreased in Group 1 over the range of preloads studied. These results suggest that hearts undergoing cardioplegic arrest had better left ventricular contractility than hearts undergoing CPB alone.