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Amin Mohamed G. Addetia
Samuel V. Lichtenstein
Tomas A. Salerno
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Ann Thorac Surg 1986;41:260-264
© 1986 The Society of Thoracic Surgeons

Articles

Study on Myocardial Contractility after Cardiopulmonary Bypass versus Cardioplegic Arrest in an Air-Ejecting In Vivo Heart Model

Amin Mohamed G. Addetia, M.D., Samuel V. Lichtenstein, M.D., Aida S. Ko, R.N., C.C.P., Maija Sikkonen, R.N., C.P., Murli Sainani, D.V.M., Tomas A. Salerno, M.D.*

From the Division of Cardiovascular Surgery, St. Michael's Hospital and the University of Toronto, Toronto, Ont, Canada

Accepted for publication May 9, 1985.

* Address reprint requests to Dr. Salerno, St. Michael's Hospital, 30 Bond St, Toronto, Ont, Canada M5B 1W8

Cardiac function was assessed in a working in vivo canine heart preparation. Minute work and myocardial oxygen consumption (MVo2) were measured after a two-hour period of hypothermic hyperkalemic crystalloid cardioplegic arrest in one group of dogs (Group 1, N = 6) and in another group of dogs on cardiopulmonary bypass (CPB) alone (Group 2, N = 6). Results indicate that at an afterload of 50 cm H20, minute work was the same in all hearts but MVo2 was significantly higher in Group 1 hearts at all levels of preload. At higher afterloads, both minute work and MVo2 were significantly greater in Group 1 hearts over the range of preloads tested. Ventricular compliance was decreased in Group 1 over the range of preloads studied. These results suggest that hearts undergoing cardioplegic arrest had better left ventricular contractility than hearts undergoing CPB alone.






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Copyright © 1986 by The Society of Thoracic Surgeons.