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The Annals of Thoracic Surgery, Vol 41, 135-142, Copyright © 1986 by The Society of Thoracic Surgeons

ARTICLES

Evaluation of the Angelchik antireflux prosthesis using a model for esophageal reflux in rhesus monkeys

DJ Cohen, SB Benjamin, GM Graeber, DO Castell, DH Patrick, C Cordova, A Dachman and A Friedman

Minimal data are available about the Angelchik antireflux prosthesis although it has been inserted in more than 14,000 patients. The present animal study was designed to evaluate the effectiveness and mechanism of action of this prosthesis. A reproducible model of esophageal reflux in primates was created using a double myotomy. Lower esophageal sphincter (LES) pressure and reflux score were improved significantly in animals by insertion of an Angelchik antireflux prosthesis, a modified antireflux prosthesis, or a Nissen fundoplication. Manometrically determined LES length was increased after insertion of an Angelchik antireflux prosthesis but not by a Nissen fundoplication or sham operation. Complications after insertion of the modified prosthesis included intraluminal erosion, fibrous stricture, and slippage of the device over the stomach.


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S S Kadirkamanathan, E Yazaki, D F Evans, C C Hepworth, F Gong, and C P Swain
An ambulant porcine model of acid reflux used to evaluate endoscopic gastroplasty
Gut, June 1, 1999; 44(6): 782 - 788.
[Abstract] [Full Text] [PDF]


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Copyright © 1986 by The Society of Thoracic Surgeons.