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Ann Thorac Surg 1985;40:113-120
© 1985 The Society of Thoracic Surgeons

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Articles

Palliation of Esophageal Malignancy with Photodynamic Therapy

From the Laser Medical Research Foundation and Grant Hospital Laser Center, Columbus, OH.

^* Address reprint requests to Dr. McCaughan, 300 E Town St, Columbus, OH 43215

Sixteen patients with espohageal malignancies received photodynamic therapy after 3 mg of hematoporphyrin derivative (Photofrin I) or 2 mg of Photofrin II per kilogram of body weight was injected intravenously two to six days prior to treatment. A tunable dye argon laser system delivered 630 nm light through quartz fibers passed through the biopsy channel of a gastroscope. All patients obtained improvement in swallowing, usually from total obstruction or clear liquids only to a regular diet within three weeks and with new techniques, at least liquids within three days of treatment.

Karnofsky Performance Status (KPS) and esophageal grades were measured before treatment, 1 month following treatment, and periodically until death. Ten patients died an average of 3.7 months after initial treatment (range, 0.6 to 19 months). Six patients are alive at 11, 10, 5, 2.5, 2 months, and 1 month after treatment. The median survival of 12 patients treated more than 6 months ago was 6.5 months and of 9 patients with an initial KPS higher than 30, 8.1 months.

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