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Ann Thorac Surg 1985;39:558-562
© 1985 The Society of Thoracic Surgeons

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Articles

The Effect of Hypothermic Preservation of the Heart and Lungs on Cardiorespiratory Function Following Canine Heart-Lung Transplantation

From the Departments of Anesthesia and Cardiovascular Surgery, Stanford University School of Medicine, Stanford, CA

Accepted for publication November 12, 1984.

^* Address reprint requests to Dr. Feeley, Department of Anesthesia, Room S-278, Stanford University School of Medicine, Stanford, CA 94305

The effect of hypothermic preservation of the heart and lungs with a crystalloid solution was evaluated in 12 mongrel dogs receiving heart-lung allografts. Six animals served as controls and received an immediate heart-lung transplant. Six animals were in the experimental group and received a heart-lung transplant after 5 hours of preservation at 4°C following perfusion of both organs with a crystalloid solution. Physiological function of the heart and lungs was studied for 20 hours after transplantation. While cardiac function was minimally depressed following preservation, pulmonary function testing demonstrated significantly greater increases in extravascular lung water in experimental animals, suggesting that an ischemic lung injury occurred with this preservation technique. The model allows for future evaluation of other methods of combined preservation of both the heart and lungs for transplantation.

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