HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Constantine Mavroudis Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wilkerson, S. A. Articles by Cook, L. N. Search for Related Content PubMed PubMed Citation Articles by Wilkerson, S. A. Articles by Cook, L. N.

Ann Thorac Surg 1985;39:541-546
© 1985 The Society of Thoracic Surgeons

---

Articles

Developmental Sequelae in Premature Infants Undergoing Ligation of Patent Ductus Arteriosus

From the Departments of Pediatrics and Surgery, Kosair Children's Hospital, University of Louisville, School of Medicine, Louisville, KY

^* Address reprint requests to Dr. Mavroudis, Department of Surgery, University of Louisville, School of Medicine, 550 S Jackson St, Louisville, KY 40202

One hundred sixteen infants who underwent on-unit ligation of patent ductus arteriosus (PDA) were examined for developmental sequelae. Mean gestational age of the study group was 29.1 weeks; mean birth weight, 1,232 gm; and mean duration of follow-up, 20.7 months (chronological age). Seven infants died of severe bronchopulmonary dysplasia (4) and severe central nervous system dysfunction (3) before they were 3 years old. Sixty-five percent of the remaining infants exhibited normal motor and mental development, although 58% showed some degree of postnatal growth retardation. There was no evidence of left arm dysfunction caused by the thoracic incision; 3 infants had minor problems with nonabsorbed sutures at 3 to 6 months of age. No infant demonstrated recurrence of ductal patency. Mild sensorineural handicaps not expected to be of long-term importance were noted in 20 infants. Eighteen other infants (15.5%) were classified as having moderate to severe impairments, which may have substantial impact on development and ability to function.

Surgical ligation of PDA in premature infants has been shown to be safe and effective in the short run. Long-term follow-up suggests that infants who undergo PDA ligation do not appear to be at increased risk for sensorineural handicaps.

This article has been cited by other articles:

				C. Mavroudis and R. M. Sade The Southern Thoracic Surgical Association 50th anniversary celebration: the impact of STSA pediatric cardiothoracic surgery manuscripts on surgical practice Ann. Thorac. Surg., November 1, 2003; 76(90050): S47 - 67. [Abstract] [Full Text] [PDF]

				R. Forster and H. H. Scheld Patent ductus arteriosus open for clipping? J. Thorac. Cardiovasc. Surg., April 1, 1994; 107(4): 1159 - 1160. [Full Text]

				R. Forster Thoracoscopic clipping of patent ductus arteriosus in premature infants Ann. Thorac. Surg., December 1, 1993; 56(6): 000349759390703K - 349759390703K. [Abstract] [PDF]