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Ann Thorac Surg 1985;39:478-480
© 1985 The Society of Thoracic Surgeons


Articles

Iodine Toxicity in a Patient Treated by Continuous Povidone-Iodine Mediastinal Irrigation

Philip L. Glick, M.D., B. Joseph Guglielmo, Pharm.D., Robert F. Tranbaugh, M.D., Kevin Turley, M.D.*

From the Departments of Surgery (Division of Cardio-Thoracic Surgery), and Pharmacy (Division of Clinical Pharmacy), University of California, San Francisco, San Francisco, CA

Accepted for publication June 13, 1984.

* Address reprint requests to Dr. Turley, Department of Surgery, UCSF, M 488, San Francisco, CA 94143

Continuous povidone-iodine irrigation is frequently used to treat mediastinitis after median sternotomy and has been considered safe and effective. We describe a 34-month-old patient with mediastinitis after median sternotomy who was treated with continuous povidone-iodine irrigation and who absorbed toxic quantities of iodine (total serum iodine, 9,375 µg/dl; normal range, 4.5 to 9.0 µg/dl). An unexplained metabolic acidosis developed, along with changes in mental status, and the patient died. This experience and a thorough review of the literature lead us to believe that continuous povidone-iodine irrigation of the mediastinum is contraindicated.




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