| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1985;39:336-339
© 1985 The Society of Thoracic Surgeons
Section of Cardiology, Department of Medicine and Division of Cardiothoracic Surgery, Department of Surgery, Northwestern University Medical School, and the Department of Nursing, Northwestern Memorial Hospital, Chicago, IL
Accepted for publication September 17, 1984.
* Address reprint requests to Dr. Davison, Suite 628, 251 E Chicago Ave, Chicago, IL 60611
This study investigated the efficacy of oral administration of verapamil, started 24 hours after coronary artery bypass grafting (CABG), in reducing the incidence of postoperative supraventricular tachyarrhythmia (SVT). Two hundred patients were randomly assigned in a double-blind fashion to receive a one-week course of either a placebo or 80 mg of verapamil every 6 hours. Overall, SVT developed in 23 control and 14 verapamil-treated patients, a 39% reduction in incidence (p < 0.10). Of the patients who received at least four doses and continued to receive the study drug, 17 in the control and 7 in the verapamil group experienced SVT, a 53% decrease in incidence (p < 0.06). Atrial fibrillation constituted 34 of the 37 SVT episodes and was associated with a slower ventricular response in the group given verapamil (115 ± 8 versus 156 ± 4 beats per minute; p < 0.001). No evidence was found linking postoperative SVT with the withdrawal of beta-blocking drugs. Adverse effects required that 20 patients in the verapamil and 6 in the placebo group be removed from the study. Hypotension or pulmonary edema or both developed in 13 of the patients receiving verapamil, but in only 1 of the control patients (p < 0.001).
We conclude that although verapamil has potential merit for the prophylaxis of SVT after CABG, its use in this setting is associated with a high incidence of unacceptable hemodynamic side effects.
This article has been cited by other articles:
|
|
 |
|
  L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, A. M. Hutter Jr, et al. 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons J. Am. Coll. Cardiol., December 6, 2011; 58(24): e123 - e210. [Full Text] [PDF]
|
|
|
|
 |
|
 Writing Committee Members, L. D. Hillis, P. K. Smith, J. L. Anderson, J. A. Bittl, C. R. Bridges, J. G. Byrne, J. E. Cigarroa, V. J. DiSesa, L. F. Hiratzka, et al. 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation, December 6, 2011; 124(23): e652 - e735. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bradley, L. L. Creswell, C. W. Hogue Jr., A. E. Epstein, E. N. Prystowsky, and E. G. Daoud Pharmacologic Prophylaxis: American College of Chest Physicians Guidelines for the Prevention and Management of Postoperative Atrial Fibrillation After Cardiac Surgery Chest, August 1, 2005; 128(2_suppl): 39S - 47S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Wijeysundera, W. S. Beattie, V. Rao, and J. Karski Calcium antagonists reduce cardiovascular complications after cardiac surgery: A meta-analysis J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1496 - 1505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tokmakoglu, O. Kandemir, S. Gunaydin, Z. Catav, C. Yorgancioglu, and Y. Zorlutuna Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation Eur J Cardiothorac Surg, March 1, 2002; 21(3): 401 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Maisel, J. D. Rawn, and W. G. Stevenson Atrial Fibrillation after Cardiac Surgery Ann Intern Med, December 18, 2001; 135(12): 1061 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Stamou, P. C. Hill, G. A. Sample, E. Snider, A. J. Pfister, R. C. Lowery, and P. J. Corso Prevention of Atrial Fibrillation After Cardiac Surgery : The Significance of Postoperative Oral Amiodarone Chest, December 1, 2001; 120(6): 1936 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Lee, C.-M. Chang, M.-J. Lu, R.-J. Lee, J.-J. Cheng, C.-R. Hung, and S.-A. Chen Intravenous amiodarone for prevention of atrial fibrillation after coronary artery bypass grafting Ann. Thorac. Surg., July 1, 2000; 70(1): 157 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Eagle, R. A. Guyton, R. Davidoff, G. A. Ewy, J. Fonger, T. J. Gardner, J. P. Gott, H. C. Herrmann, R. A. Marlow, W. C. Nugent, et al. ACC/AHA guidelines for coronary artery bypass graft surgery: A report of the American College of Cardiology/ American Heart Association task force on Practice Guidelines (Committee to revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery) J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1262 - 1347. [Full Text] [PDF]
|
|
|
|
|
|
V. Ducceschi, A. D'Andrea, B. Liccardo, A. Alfieri, B. Sarubbi, M. De Feo, L. Santangelo, and M. Cotrufo Perioperative clinical predictors of atrial fibrillation occurrence following coronary artery surgery Eur J Cardiothorac Surg, October 1, 1999; 16(4): 435 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mehmanesh, R. Lange, and S. Hagl Temporary Atrial Electrode for the Treatment of Supraventricular Tachycardia After Cardiac Operations Ann. Thorac. Surg., March 1, 1998; 65(3): 632 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Kloter Weber, S. Osswald, P. Buser, M. Huber, K. Skarvan, P. Stulz, and M. Pfisterer Significance of Supraventricular Tachyarrhythmias After Coronary Artery Bypass Graft Surgery and Their Prevention by Low-Dose Sotalol: A Prospective Double-Blind Randomized Placebo-Controlled Study Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(3): 209 - 216. [Abstract] [PDF]
|
|
|
|
|
|
M. E. Pfisterer, U. C. D. Kloter-Weber, M. Huber, S. Osswald, P. T. Buser, K. Skarvan, and P. M. Stulz Prevention of Supraventricular Tachyarrhythmias After Open Heart Operation by Low-Dose Sotalol: A Prospective, Double-Blind, Randomized, Placebo-Controlled Study Ann. Thorac. Surg., October 1, 1997; 64(4): 1113 - 1119. [Abstract] [Full Text]
|
|
|
|
|
|
W. Van Mieghem, G. Tits, K. Demuynck, L. Lacquet, G. Deneffe, T. Tjandra-Maga, and M. Demedts Verapamil as Prophylactic Treatment for Atrial Fibrillation After Lung Operations Ann. Thorac. Surg., April 1, 1996; 61(4): 1083 - 1085. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Cox A perspective of postoperative atrial fibrillation in cardiac operations Ann. Thorac. Surg., September 1, 1993; 56(3): 405 - 409. [PDF]
|
|
|
|
|
|
V. A. Ferraris, S. P. Ferraris, H. Gilliam, and W. Berry Verapamil Prophylaxis for Postoperative Atrial Dysrhythmias: A Prospective, Randomized, Double-blind Study Using Drug Level Monitoring Ann. Thorac. Surg., May 1, 1987; 43(5): 530 - 533. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
