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Ann Thorac Surg 1985;39:303-307
© 1985 The Society of Thoracic Surgeons

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Articles

Cardiac Transplantation at the Texas Heart Institute: Comparative Analysis of Two Groups of Patients (1968–1969 and 1982–1983)

Cardiovascular Surgical Research Laboratories, Transplantation Unit, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Houston, TX

Accepted for publication June 22, 1984.

^* Address reprint requests to Dr. Frazier, Texas Heart Institute, PO Box 20345, Houston, TX 77225

Two groups of heart transplant recipients were studied. Patients in Group 1 underwent heart transplantation from May, 1968, to November, 1969. They were compared with Group 2, a series begun in July, 1982, when the current cardiac transplantation program was renewed at the Texas Heart Institute, and terminated in December, 1983.

Patient selection, management, and results were compared. With a cumulative follow-up of 64 patient-months (Group 1) versus 93 patient-months (Group 2), the actuarial 18-month survival was 0 in Group 1 versus 70% in Group 2.

Nine of the 18 patients in Group 1 died of rejection versus 4 of the 18 patients in Group 2. There were 6 infection-related deaths in Group 1 and none in Group 2. Using linearized rates based on 100 patient-months, the incidences of rejection and infection were, respectively, 23 versus 10.7 (p < 0.05) and 64 versus 34 (p < 0.05) between Groups 1 and 2. Incidence, pattern, and severity of these major complications have been reduced significantly. Over the last decade, there have been improvements in the selection of potential candidates, better management of donors, improved graft preservation, and the introduction of more selective immunosuppression.

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				M. S. Sweeney, M. P. Macris, O. H. Frazier, J. T. Sinnott, M. Peric, and H. A. McAllister Jr The Treatment of Advanced Cardiac Allograft Rejection Ann. Thorac. Surg., October 1, 1988; 46(4): 378 - 381. [Abstract] [PDF]